ENSG00000081760


Homo sapiens

Features
Gene ID: ENSG00000081760
  
Biological name :AACS
  
Synonyms : AACS / acetoacetyl-CoA synthetase / Q86V21
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.31
Gene start: 125065379
Gene end: 125143333
  
Corresponding Affymetrix probe sets: 218434_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000324842
Ensembl peptide - ENSP00000416461
NCBI entrez gene - 65985     See in Manteia.
OMIM - 614364
RefSeq - XM_011538692
RefSeq - NM_001319839
RefSeq - NM_001319840
RefSeq - NM_023928
RefSeq Peptide - NP_001306768
RefSeq Peptide - NP_001306769
RefSeq Peptide - NP_076417
swissprot - A0A024RBV2
swissprot - E7EW25
swissprot - Q86V21
Ensembl - ENSG00000081760
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aacsENSDARG00000012468Danio rerio
 AACSENSGALG00000002899Gallus gallus
 AacsENSMUSG00000029482Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000873  AMP-dependent synthetase/ligase
 IPR005914  Acetoacetyl-CoA synthase
 IPR020845  AMP-binding, conserved site
 IPR032387  Acetyl-coenzyme A synthetase, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014074 response to purine-containing compound IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0034201 response to oleic acid IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046951 ketone body biosynthetic process TAS
 biological_processGO:0050872 white fat cell differentiation IEA
 biological_processGO:0060612 adipose tissue development IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071394 cellular response to testosterone stimulus IEA
 biological_processGO:0071397 cellular response to cholesterol IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0030729 acetoacetate-CoA ligase activity TAS
 molecular_functionGO:0047760 butyrate-CoA ligase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of Ketone Bodies


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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