ENSG00000087237


Homo sapiens

Features
Gene ID: ENSG00000087237
  
Biological name :CETP
  
Synonyms : CETP / cholesteryl ester transfer protein / P11597
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q13
Gene start: 56961850
Gene end: 56983845
  
Corresponding Affymetrix probe sets: 206210_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000200676
Ensembl peptide - ENSP00000456276
Ensembl peptide - ENSP00000369106
NCBI entrez gene - 1071     See in Manteia.
OMIM - 118470
RefSeq - NM_001286085
RefSeq - NM_000078
RefSeq Peptide - NP_000069
RefSeq Peptide - NP_001273014
swissprot - P11597
swissprot - A0A0S2Z3F6
swissprot - H3BRJ9
swissprot - A0A0S2Z3I8
Ensembl - ENSG00000087237
  
Related genetic diseases (OMIM): 143470 - Hyperalphalipoproteinemia, 143470
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cetpENSDARG00000030872Danio rerio
 CETPENSGALG00000001234Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001124  Lipid-binding serum glycoprotein, C-terminal
 IPR017130  Cholesteryl ester transfer
 IPR017942  Lipid-binding serum glycoprotein, N-terminal
 IPR017943  Bactericidal permeability-increasing protein, alpha/beta domain superfamily
 IPR017954  Lipid-binding serum glycoprotein, conserved site
 IPR032942  BPI/LBP/Plunc family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006641 triglyceride metabolic process IDA
 biological_processGO:0006869 lipid transport IDA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IMP
 biological_processGO:0010745 negative regulation of macrophage derived foam cell differentiation IC
 biological_processGO:0010874 regulation of cholesterol efflux IMP
 biological_processGO:0015914 phospholipid transport IDA
 biological_processGO:0030301 cholesterol transport IDA
 biological_processGO:0034197 triglyceride transport IDA
 biological_processGO:0034372 very-low-density lipoprotein particle remodeling IDA
 biological_processGO:0034374 low-density lipoprotein particle remodeling TAS
 biological_processGO:0034375 high-density lipoprotein particle remodeling IDA
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0043691 reverse cholesterol transport IEA
 biological_processGO:0046470 phosphatidylcholine metabolic process IDA
 biological_processGO:0055088 lipid homeostasis IDA
 biological_processGO:0055091 phospholipid homeostasis IDA
 biological_processGO:0070328 triglyceride homeostasis IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0034364 high-density lipoprotein particle IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005319 lipid transporter activity IDA
 molecular_functionGO:0005548 phospholipid transporter activity IDA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0015485 cholesterol binding IDA
 molecular_functionGO:0017127 cholesterol transporter activity IEA
 molecular_functionGO:0017129 triglyceride binding IDA
 molecular_functionGO:0031210 phosphatidylcholine binding IDA


Pathways (from Reactome)
Pathway description
LDL remodeling
HDL remodeling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0003077 Hyperlipidemia 
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 HP:0003124 Hypercholesterolemia 
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 HP:0012153 Hypotriglyceridemia "An decrease in the level of `triglycerides` (CHEBI:17855) in the `blood` (FMA:9670)." [HPO:probinson]
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 HP:0012184 Hyperalphalipoproteinemia "An elevated concentration of `high-density lipoprotein cholesterol` (CHEBI:47775) (HDL) in the `blood` (FMA:9670)." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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