ENSG00000100342


Homo sapiens

Features
Gene ID: ENSG00000100342
  
Biological name :APOL1
  
Synonyms : APOL1 / apolipoprotein L1 / O14791
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q12.3
Gene start: 36253010
Gene end: 36267530
  
Corresponding Affymetrix probe sets: 209546_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000392514
Ensembl peptide - ENSP00000392857
Ensembl peptide - ENSP00000411507
Ensembl peptide - ENSP00000404525
Ensembl peptide - ENSP00000397141
Ensembl peptide - ENSP00000317674
Ensembl peptide - ENSP00000380448
Ensembl peptide - ENSP00000380449
Ensembl peptide - ENSP00000388477
Ensembl peptide - ENSP00000391206
Ensembl peptide - ENSP00000391302
NCBI entrez gene - 8542     See in Manteia.
OMIM - 603743
RefSeq - XM_011530478
RefSeq - NM_001136540
RefSeq - NM_001136541
RefSeq - NM_003661
RefSeq - NM_145343
RefSeq - XM_005261796
RefSeq Peptide - NP_663318
RefSeq Peptide - NP_001130012
RefSeq Peptide - NP_001130013
RefSeq Peptide - NP_003652
swissprot - F8WCH3
swissprot - B1AH95
swissprot - B1AH94
swissprot - O14791
swissprot - B1AH96
swissprot - F8WB77
Ensembl - ENSG00000100342
  
Related genetic diseases (OMIM): 612551 - {End-stage renal disease, nondiabetic, susceptibility to}, 612551
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch73-233k15.2ENSDARG00000073718Danio rerio
 Apol10aENSMUSG00000050982Mus musculus
 Apol10bENSMUSG00000050014Mus musculus
 Apol11aENSMUSG00000091650Mus musculus
 Apol11bENSMUSG00000091694Mus musculus
 Apol7aENSMUSG00000010601Mus musculus
 Apol7bENSMUSG00000068252Mus musculus
 Apol7cENSMUSG00000044309Mus musculus
 Apol7eENSMUSG00000071716Mus musculus
 Apol8ENSMUSG00000056656Mus musculus
 Apol9aENSMUSG00000057346Mus musculus
 Apol9bENSMUSG00000068246Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
APOL2 / Q9BQE5 / apolipoprotein L2ENSG0000012833550
APOL3 / O95236 / apolipoprotein L3ENSG0000012828438
APOL4 / Q9BPW4 / apolipoprotein L4ENSG0000010033632
APOL6 / Q9BWW8 / apolipoprotein L6ENSG0000022196324
APOL5 / Q9BWW9 / apolipoprotein L5ENSG0000012831321


Protein motifs (from Interpro)
Interpro ID Name
 IPR008405  Apolipoprotein L


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0019835 cytolysis IDA
 biological_processGO:0031640 killing of cells of other organism IDA
 biological_processGO:0042157 lipoprotein metabolic process IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045087 innate immune response IDA
 biological_processGO:1902476 chloride transmembrane transport IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0031224 intrinsic component of membrane IC
 cellular_componentGO:0034361 very-low-density lipoprotein particle IDA
 cellular_componentGO:0034364 high-density lipoprotein particle IDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0005254 chloride channel activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IDA


Pathways (from Reactome)
Pathway description
Scavenging of heme from plasma
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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