ENSG00000101473


Homo sapiens

Features
Gene ID: ENSG00000101473
  
Biological name :ACOT8
  
Synonyms : ACOT8 / acyl-CoA thioesterase 8 / O14734
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q13.12
Gene start: 45841721
Gene end: 45857406
  
Corresponding Affymetrix probe sets: 204212_at (Human Genome U133 Plus 2.0 Array)   236514_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000419403
Ensembl peptide - ENSP00000435581
Ensembl peptide - ENSP00000435115
Ensembl peptide - ENSP00000434216
Ensembl peptide - ENSP00000433923
Ensembl peptide - ENSP00000431175
Ensembl peptide - ENSP00000217455
Ensembl peptide - ENSP00000403862
Ensembl peptide - ENSP00000416217
NCBI entrez gene - 10005     See in Manteia.
OMIM - 608123
RefSeq - NM_005469
RefSeq - XM_005260239
RefSeq - XM_011528480
RefSeq Peptide - NP_005460
swissprot - H0Y698
swissprot - E9PRD4
swissprot - O14734
swissprot - Q9BR14
swissprot - H7C5A7
swissprot - E9PMC4
swissprot - E9PJN0
swissprot - E9PIS4
swissprot - F6VBM3
Ensembl - ENSG00000101473
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acot8ENSDARG00000014138Danio rerio
 ACOT8ENSGALG00000006842Gallus gallus
 Acot8ENSMUSG00000017307Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003703  Acyl-CoA thioesterase
 IPR029069  HotDog domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006637 acyl-CoA metabolic process IEA
 biological_processGO:0006699 bile acid biosynthetic process TAS
 biological_processGO:0007031 peroxisome organization IEA
 biological_processGO:0009062 fatty acid catabolic process IBA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016559 peroxisome fission IDA
 biological_processGO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase TAS
 biological_processGO:0036109 alpha-linolenic acid metabolic process TAS
 biological_processGO:0043649 dicarboxylic acid catabolic process IDA
 biological_processGO:0045225 negative regulation of CD4 biosynthetic process IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005782 peroxisomal matrix IMP
 molecular_functionGO:0003986 acetyl-CoA hydrolase activity TAS
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016289 CoA hydrolase activity TAS
 molecular_functionGO:0016290 palmitoyl-CoA hydrolase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0033882 choloyl-CoA hydrolase activity IEA
 molecular_functionGO:0047617 acyl-CoA hydrolase activity IEA
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA
 molecular_functionGO:0052815 medium-chain acyl-CoA hydrolase activity IDA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
alpha-linolenic acid (ALA) metabolism
Beta-oxidation of pristanoyl-CoA
Beta-oxidation of very long chain fatty acids
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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