ENSG00000102901


Homo sapiens

Features
Gene ID: ENSG00000102901
  
Biological name :CENPT
  
Synonyms : CENPT / centromere protein T / Q96BT3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q22.1
Gene start: 67828157
Gene end: 67847811
  
Corresponding Affymetrix probe sets: 218148_at (Human Genome U133 Plus 2.0 Array)   226788_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000487410
Ensembl peptide - ENSP00000460542
Ensembl peptide - ENSP00000461212
Ensembl peptide - ENSP00000400140
Ensembl peptide - ENSP00000454481
Ensembl peptide - ENSP00000454627
Ensembl peptide - ENSP00000455638
Ensembl peptide - ENSP00000455801
Ensembl peptide - ENSP00000455918
Ensembl peptide - ENSP00000456714
Ensembl peptide - ENSP00000457294
Ensembl peptide - ENSP00000457304
Ensembl peptide - ENSP00000457810
Ensembl peptide - ENSP00000457832
NCBI entrez gene - 80152     See in Manteia.
OMIM - 611510
RefSeq - XM_017023716
RefSeq - NM_025082
RefSeq - XM_006721277
RefSeq - XM_011523344
RefSeq - XM_017023712
RefSeq - XM_017023713
RefSeq - XM_017023714
RefSeq - XM_017023715
RefSeq Peptide - NP_079358
swissprot - H3BMP6
swissprot - Q96BT3
swissprot - H3BN05
swissprot - H3BQ71
swissprot - H3BQJ0
swissprot - H3BQS6
swissprot - H3BTR4
swissprot - H3BTS2
swissprot - I3L4F8
swissprot - H3BUW2
Ensembl - ENSG00000102901
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-225g23.1ENSDARG00000091271Danio rerio
 CENPTENSGALG00000028900Gallus gallus
 CenptENSMUSG00000036672Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009072  Histone-fold
 IPR028255  Centromere protein T
 IPR032373  Centromere kinetochore component CENP-T, N-terminal domain
 IPR035425  CENP-T/Histone H4, histone fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IMP
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0034080 CENP-A containing nucleosome assembly TAS
 biological_processGO:0051276 chromosome organization IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051382 kinetochore assembly IEA
 biological_processGO:1903394 protein localization to kinetochore involved in kinetochore assembly IBA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000788 nuclear nucleosome IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042393 histone binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Deposition of new CENPA-containing nucleosomes at the centromere
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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