ENSG00000105327


Homo sapiens

Features
Gene ID: ENSG00000105327
  
Biological name :BBC3
  
Synonyms : BBC3 / BCL2 binding component 3 / Q96PG8 / Q9BXH1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.32
Gene start: 47220822
Gene end: 47232766
  
Corresponding Affymetrix probe sets: 211692_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000300880
Ensembl peptide - ENSP00000341155
Ensembl peptide - ENSP00000395862
Ensembl peptide - ENSP00000404503
NCBI entrez gene - 27113     See in Manteia.
OMIM - 605854
RefSeq - XM_011526722
RefSeq - NM_001127240
RefSeq - NM_001127241
RefSeq - NM_001127242
RefSeq - NM_014417
RefSeq - XM_006723141
RefSeq Peptide - NP_001120714
RefSeq Peptide - NP_055232
RefSeq Peptide - NP_001120712
RefSeq Peptide - NP_001120713
swissprot - Q96PG8
swissprot - Q9BXH1
Ensembl - ENSG00000105327
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR031661  Bcl-2-binding component 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001836 release of cytochrome c from mitochondria IDA
 biological_processGO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISS
 biological_processGO:0008340 determination of adult lifespan ISS
 biological_processGO:0032464 positive regulation of protein homooligomerization IDA
 biological_processGO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration IDA
 biological_processGO:0034976 response to endoplasmic reticulum stress IDA
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process ISS
 biological_processGO:0045926 negative regulation of growth IMP
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IDA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
 biological_processGO:0070245 positive regulation of thymocyte apoptotic process ISS
 biological_processGO:0071456 cellular response to hypoxia IEP
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IDA
 biological_processGO:0097193 intrinsic apoptotic signaling pathway IEA
 biological_processGO:0097194 execution phase of apoptosis IDA
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway IDA
 biological_processGO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway TAS
 biological_processGO:1903896 positive regulation of IRE1-mediated unfolded protein response TAS
 biological_processGO:2001056 positive regulation of cysteine-type endopeptidase activity ISS
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway TAS
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane TAS
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051117 ATPase binding IPI


Pathways (from Reactome)
Pathway description
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000171791 BCL2 / P10415 / BCL2, apoptosis regulator  / complex / reaction






 

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