ENSG00000105483


Homo sapiens

Features
Gene ID: ENSG00000105483
  
Biological name :CARD8
  
Synonyms : CARD8 / caspase recruitment domain family member 8 / Q9Y2G2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.33
Gene start: 48180770
Gene end: 48255946
  
Corresponding Affymetrix probe sets: 1554479_a_at (Human Genome U133 Plus 2.0 Array)   204950_at (Human Genome U133 Plus 2.0 Array)   228641_at (Human Genome U133 Plus 2.0 Array)   232969_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429839
Ensembl peptide - ENSP00000429741
Ensembl peptide - ENSP00000430057
Ensembl peptide - ENSP00000430836
Ensembl peptide - ENSP00000430747
Ensembl peptide - ENSP00000430567
Ensembl peptide - ENSP00000430495
Ensembl peptide - ENSP00000430460
Ensembl peptide - ENSP00000430178
Ensembl peptide - ENSP00000430108
Ensembl peptide - ENSP00000375767
Ensembl peptide - ENSP00000391248
Ensembl peptide - ENSP00000427727
Ensembl peptide - ENSP00000427858
Ensembl peptide - ENSP00000427922
Ensembl peptide - ENSP00000428662
Ensembl peptide - ENSP00000428736
Ensembl peptide - ENSP00000428862
Ensembl peptide - ENSP00000428883
Ensembl peptide - ENSP00000428975
Ensembl peptide - ENSP00000429362
NCBI entrez gene - 22900     See in Manteia.
OMIM - 609051
RefSeq - XM_017026499
RefSeq - XM_011526648
RefSeq - XM_011526650
RefSeq - XM_011526653
RefSeq - XM_017026482
RefSeq - XM_017026483
RefSeq - XM_017026484
RefSeq - XM_017026485
RefSeq - XM_017026486
RefSeq - XM_017026487
RefSeq - XM_017026488
RefSeq - XM_017026489
RefSeq - XM_017026490
RefSeq - XM_017026491
RefSeq - XM_017026492
RefSeq - XM_017026493
RefSeq - XM_017026494
RefSeq - XM_017026495
RefSeq - XM_017026496
RefSeq - XM_017026497
RefSeq - XM_017026498
RefSeq - NM_001184900
RefSeq - NM_001184901
RefSeq - NM_001184902
RefSeq - NM_001184903
RefSeq - NM_001184904
RefSeq - NM_001351783
RefSeq - NM_001351784
RefSeq - NM_014959
RefSeq - XM_006723091
RefSeq - XM_006723092
RefSeq - XM_006723093
RefSeq - XM_006723094
RefSeq - XM_006723095
RefSeq - XM_006723096
RefSeq - XM_006723097
RefSeq - XM_006723098
RefSeq - XM_006723099
RefSeq - XM_006723101
RefSeq - XM_006723102
RefSeq - XM_006723104
RefSeq - XM_006723106
RefSeq - XM_006723107
RefSeq - XM_006723109
RefSeq - XM_006723110
RefSeq - XM_011526641
RefSeq - XM_011526642
RefSeq - XM_011526643
RefSeq - XM_011526644
RefSeq - XM_011526646
RefSeq - XM_011526647
RefSeq Peptide - NP_001171831
RefSeq Peptide - NP_001171832
RefSeq Peptide - NP_001171833
RefSeq Peptide - NP_001338711
RefSeq Peptide - NP_001338712
RefSeq Peptide - NP_001338713
RefSeq Peptide - NP_055774
RefSeq Peptide - NP_001171829
RefSeq Peptide - NP_001171830
swissprot - Q9Y2G2
swissprot - E5RFI5
swissprot - E5RJG3
swissprot - E5RIN1
swissprot - E5RHZ3
swissprot - E5RHJ3
swissprot - E5RGG3
swissprot - E5RGC9
swissprot - E5RFV9
swissprot - H0YB90
swissprot - H0YBW7
Ensembl - ENSG00000105483
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000007698Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR011029  Death-like domain superfamily
 IPR025307  FIIND domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IMP
 biological_processGO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway IDA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0050713 negative regulation of interleukin-1 beta secretion IDA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IDA
 biological_processGO:0097340 inhibition of cysteine-type endopeptidase activity IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0072559 NLRP3 inflammasome complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IDA
 molecular_functionGO:0032089 NACHT domain binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0050700 CARD domain binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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