ENSG00000107789


Homo sapiens

Features
Gene ID: ENSG00000107789
  
Biological name :MINPP1
  
Synonyms : MINPP1 / multiple inositol-polyphosphate phosphatase 1 / Q9UNW1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q23.2
Gene start: 87504875
Gene end: 87553460
  
Corresponding Affymetrix probe sets: 209585_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000361062
Ensembl peptide - ENSP00000361064
Ensembl peptide - ENSP00000437823
NCBI entrez gene - 9562     See in Manteia.
OMIM - 605391
RefSeq - XM_017016966
RefSeq - NM_001178117
RefSeq - NM_001178118
RefSeq - NM_004897
RefSeq - XM_006718078
RefSeq - XM_011540379
RefSeq Peptide - NP_001171588
RefSeq Peptide - NP_001171589
RefSeq Peptide - NP_004888
swissprot - Q9UNW1
Ensembl - ENSG00000107789
  
Related genetic diseases (OMIM): 188470 - Thyroid carcinoma, follicular, 188470
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 minpp1aENSDARG00000057058Danio rerio
 minpp1bENSDARG00000045172Danio rerio
 MINPP1ENSGALG00000003695Gallus gallus
 Minpp1ENSMUSG00000024896Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000560  Histidine phosphatase superfamily, clade-2
 IPR016274  Histidine acid phosphatase, eukaryotic
 IPR029033  Histidine phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification NAS
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006797 polyphosphate metabolic process TAS
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030282 bone mineralization NAS
 biological_processGO:0043647 inositol phosphate metabolic process TAS
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003993 acid phosphatase activity IBA
 molecular_functionGO:0004446 inositol-hexakisphosphate phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0030351 inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity TAS
 molecular_functionGO:0034417 bisphosphoglycerate 3-phosphatase activity IDA
 molecular_functionGO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity TAS
 molecular_functionGO:0052745 inositol phosphate phosphatase activity IBA
 molecular_functionGO:0052826 inositol hexakisphosphate 2-phosphatase activity TAS
 molecular_functionGO:0101006 protein histidine phosphatase activity TAS


Pathways (from Reactome)
Pathway description
Synthesis of IPs in the ER lumen


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0001939 Metabolism abnormality 
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 HP:0002176 Spinal cord compression 
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 HP:0002653 Bone pain 
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 HP:0002730 Chronic noninfectious lymphadenopathy 
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 HP:0002757 Recurrent fractures "The repeated occurence of bone fractures (implying an abnormally increased tendency for fracture)." [HPO:curators]
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 HP:0002895 Papillary thyroid carcinoma 
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 HP:0003003 Colon cancer 
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 HP:0005994 Nodular goiter 
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 HP:0006528 Chronic lung disease 
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 HP:0006731 Follicular thyroid carcinoma 
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 HP:0006766 Papillary renal cell carcinoma 
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 HP:0012288 Neoplasm of head and neck "A neoplasm of the head and neck region with origin in the lip, oral cavity, nasal cavity, paranasal sinuses, pharynx, and larynx." [HPO:probinson]
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 HP:0040198 Non-medullary thyroid carcinoma 
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 HP:3000037 Abnormality of neck blood vessel "An abnormality of a blood vessel of the neck, including branches of the arterial and venous systems of the neck." [GOC:TermGenie, orcid.org/0000-0001-5889-4463]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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