ENSG00000112299


Homo sapiens

Features
Gene ID: ENSG00000112299
  
Biological name :VNN1
  
Synonyms : O95497 / vanin 1 / VNN1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q23.2
Gene start: 132681590
Gene end: 132714049
  
Corresponding Affymetrix probe sets: 1558549_s_at (Human Genome U133 Plus 2.0 Array)   205844_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356905
NCBI entrez gene - 8876     See in Manteia.
OMIM - 603570
RefSeq - NM_004666
RefSeq Peptide - NP_004657
swissprot - O95497
Ensembl - ENSG00000112299
  
Related genetic diseases (OMIM): 603570 - [High density lipoprotein cholesterol level QTL 8]
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 VNN1ENSGALG00000013993Gallus gallus
 Vnn1ENSMUSG00000037440Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
VNN2 / O95498 / vanin 2ENSG0000011230362
BTD / P43251 / biotinidaseENSG0000016981441
VNN3 / Q9NY84 / vanin 3ENSG0000009313433


Protein motifs (from Interpro)
Interpro ID Name
 IPR003010  Carbon-nitrogen hydrolase
 IPR012101  Biotinidase-like, eukaryotic
 IPR036526  Carbon-nitrogen hydrolase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002526 acute inflammatory response ISS
 biological_processGO:0002544 chronic inflammatory response IEA
 biological_processGO:0006501 C-terminal protein lipidation TAS
 biological_processGO:0006807 nitrogen compound metabolic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006979 response to oxidative stress TAS
 biological_processGO:0015939 pantothenate metabolic process TAS
 biological_processGO:0033089 positive regulation of T cell differentiation in thymus ISS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0098609 cell-cell adhesion ISS
 biological_processGO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0035577 azurophil granule membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
 molecular_functionGO:0017159 pantetheine hydrolase activity TAS


Pathways (from Reactome)
Pathway description
Post-translational modification: synthesis of GPI-anchored proteins
Vitamin B5 (pantothenate) metabolism
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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