ENSG00000123739


Homo sapiens

Features
Gene ID: ENSG00000123739
  
Biological name :PLA2G12A
  
Synonyms : phospholipase A2 group XIIA / PLA2G12A / Q9BZM1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q25
Gene start: 109709989
Gene end: 109730077
  
Corresponding Affymetrix probe sets: 221027_s_at (Human Genome U133 Plus 2.0 Array)   223373_s_at (Human Genome U133 Plus 2.0 Array)   228084_at (Human Genome U133 Plus 2.0 Array)   242323_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000243501
Ensembl peptide - ENSP00000425274
Ensembl peptide - ENSP00000424021
NCBI entrez gene - 81579     See in Manteia.
OMIM - 611652
RefSeq - NM_030821
RefSeq Peptide - NP_110448
swissprot - D6RBP5
swissprot - A0A0C4DGC6
swissprot - Q542Y6
swissprot - Q9BZM1
Ensembl - ENSG00000123739
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pla2g12aENSDARG00000070454Danio rerio
 PLA2G12AENSGALG00000012185Gallus gallus
 Q9EPR2ENSMUSG00000027999Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9BX93 / PLA2G12B / phospholipase A2 group XIIBENSG0000013830842


Protein motifs (from Interpro)
Interpro ID Name
 IPR010711  Group XII secretory phospholipase A2 precursor
 IPR033113  Phospholipase A2, histidine active site
 IPR036444  Phospholipase A2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process IEA
 biological_processGO:0006654 phosphatidic acid biosynthetic process TAS
 biological_processGO:0008150 biological_process ND
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0036148 phosphatidylglycerol acyl-chain remodeling TAS
 biological_processGO:0036149 phosphatidylinositol acyl-chain remodeling TAS
 biological_processGO:0036150 phosphatidylserine acyl-chain remodeling TAS
 biological_processGO:0036151 phosphatidylcholine acyl-chain remodeling TAS
 biological_processGO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS
 biological_processGO:0050482 arachidonic acid secretion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 molecular_functionGO:0004623 phospholipase A2 activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047498 calcium-dependent phospholipase A2 activity NAS
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr