ENSG00000128965


Homo sapiens

Features
Gene ID: ENSG00000128965
  
Biological name :CHAC1
  
Synonyms : CHAC1 / ChaC glutathione specific gamma-glutamylcyclotransferase 1 / Q9BUX1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q15.1
Gene start: 40952962
Gene end: 40956519
  
Corresponding Affymetrix probe sets: 219270_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000395466
Ensembl peptide - ENSP00000452707
Ensembl peptide - ENSP00000481816
Ensembl peptide - ENSP00000484644
Ensembl peptide - ENSP00000398105
NCBI entrez gene - 79094     See in Manteia.
OMIM - 614587
RefSeq - XM_017022565
RefSeq - NM_001142776
RefSeq - NM_024111
RefSeq - XM_017022563
RefSeq - XM_017022564
RefSeq Peptide - NP_077016
RefSeq Peptide - NP_001136248
swissprot - H0YK90
swissprot - Q9BUX1
swissprot - A0A0C4DGX1
Ensembl - ENSG00000128965
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chac1ENSDARG00000070426Danio rerio
 CHAC1ENSGALG00000027874Gallus gallus
 Chac1ENSMUSG00000027313Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CHAC2 / Q8WUX2 / ChaC cation transport regulator homolog 2ENSG0000014394234


Protein motifs (from Interpro)
Interpro ID Name
 IPR006840  Glutathione-specific gamma-glutamylcyclotransferase
 IPR013024  Gamma-glutamyl cyclotransferase-like
 IPR036568  Gamma-glutamyl cyclotransferase-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006750 glutathione biosynthetic process TAS
 biological_processGO:0006751 glutathione catabolic process IBA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010955 negative regulation of protein processing IMP
 biological_processGO:0022008 neurogenesis ISS
 biological_processGO:0045746 negative regulation of Notch signaling pathway IMP
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network ISS
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003839 gamma-glutamylcyclotransferase activity IBA
 molecular_functionGO:0005112 Notch binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016829 lyase activity IEA


Pathways (from Reactome)
Pathway description
Glutathione synthesis and recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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