ENSG00000134107


Homo sapiens

Features
Gene ID: ENSG00000134107
  
Biological name :BHLHE40
  
Synonyms : basic helix-loop-helix family member e40 / BHLHE40 / O14503
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p26.1
Gene start: 4979116
Gene end: 4985323
  
Corresponding Affymetrix probe sets: 201169_s_at (Human Genome U133 Plus 2.0 Array)   201170_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000256495
NCBI entrez gene - 8553     See in Manteia.
OMIM - 604256
RefSeq - NM_003670
RefSeq Peptide - NP_003661
swissprot - O14503
swissprot - Q6IB83
Ensembl - ENSG00000134107
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bhlhe40ENSDARG00000004060Danio rerio
 BHLHE40ENSGALG00000008308Gallus gallus
 O35185ENSMUSG00000030103Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9C0J9 / BHLHE41 / basic helix-loop-helix family member e41ENSG0000012309540


Protein motifs (from Interpro)
Interpro ID Name
 IPR003650  Orange domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated NAS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009416 response to light stimulus IEA
 biological_processGO:0032922 circadian regulation of gene expression IDA
 biological_processGO:0043153 entrainment of circadian clock by photoperiod ISS
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048511 rhythmic process IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IEA
 molecular_functionGO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043425 bHLH transcription factor binding IPI
 molecular_functionGO:0043426 MRF binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IDA


Pathways (from Reactome)
Pathway description
BMAL1:CLOCK,NPAS2 activates circadian gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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