ENSG00000140326


Homo sapiens

Features
Gene ID: ENSG00000140326
  
Biological name :CDAN1
  
Synonyms : CDAN1 / codanin 1 / Q8IWY9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q15.2
Gene start: 42723544
Gene end: 42737128
  
Corresponding Affymetrix probe sets: 228516_at (Human Genome U133 Plus 2.0 Array)   231080_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000348564
Ensembl peptide - ENSP00000454246
Ensembl peptide - ENSP00000455536
Ensembl peptide - ENSP00000494699
NCBI entrez gene - 146059     See in Manteia.
OMIM - 607465
RefSeq - XM_011521274
RefSeq - NM_138477
RefSeq - XM_005254176
RefSeq - XM_011521270
RefSeq - XM_011521271
RefSeq Peptide - NP_612486
swissprot - H3BPZ6
swissprot - H3BM60
swissprot - Q8IWY9
Ensembl - ENSG00000140326
  
Related genetic diseases (OMIM): 224120 - Dyserythropoietic anemia, congenital, type Ia, 224120
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdan1ENSDARG00000042261Danio rerio
 CDAN1ENSGALG00000009156Gallus gallus
 Cdan1ENSMUSG00000027284Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR028171  Codanin-1, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IMP
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0008156 negative regulation of DNA replication IMP
 biological_processGO:0031497 chromatin assembly IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0001159 Syndactyly "Webbing or fusion of the fingers or toes, involving soft parts only or including bone structure. Bony fusions are revered to as "bony" Syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the fingers or toes in a proximo-distal axis are refered to as "Symphalangism"." [HPO:curators]
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 HP:0001530 Growth retardation, mild 
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 HP:0001744 Splenomegaly "An abnormal enlargement of the spleen." [HPO:curators]
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 HP:0001789 Hydrops fetalis 
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 HP:0001923 Reticulocytosis 
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 HP:0003352 Endopolyploidy on chromosome studies of bone marrow 
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 HP:0003655 Deficient N-acetylglucosaminyltransferase II 
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 HP:0004447 Poikilocytosis 
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 HP:0005532 Macrocytic dyserythropoietic anemia 
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 HP:0006579 Prolonged neonatal jaundice 
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 HP:0011273 Anisocytosis "Abnormally increased variability in the size of erythrocytes." [HPO:probinson]
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 HP:0012132 Erythroid hyperplasia "Increased count of erythroid precursor cells, that is, `erythroid lineage cells` (CL:0000764) in the bone marrow." [DDD:akelly]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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