ENSG00000144824


Homo sapiens

Features
Gene ID: ENSG00000144824
  
Biological name :PHLDB2
  
Synonyms : PHLDB2 / pleckstrin homology like domain family B member 2 / Q86SQ0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q13.2
Gene start: 111732497
Gene end: 111976517
  
Corresponding Affymetrix probe sets: 1554778_at (Human Genome U133 Plus 2.0 Array)   1554779_s_at (Human Genome U133 Plus 2.0 Array)   1557578_at (Human Genome U133 Plus 2.0 Array)   225688_s_at (Human Genome U133 Plus 2.0 Array)   238419_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000417497
Ensembl peptide - ENSP00000418198
Ensembl peptide - ENSP00000492652
Ensembl peptide - ENSP00000492282
Ensembl peptide - ENSP00000491559
Ensembl peptide - ENSP00000420303
Ensembl peptide - ENSP00000418319
Ensembl peptide - ENSP00000418296
Ensembl peptide - ENSP00000377500
Ensembl peptide - ENSP00000377502
Ensembl peptide - ENSP00000405292
Ensembl peptide - ENSP00000405405
NCBI entrez gene - 90102     See in Manteia.
OMIM - 610298
RefSeq - NM_001134438
RefSeq - NM_001134439
RefSeq - NM_145753
RefSeq - NM_001134437
RefSeq Peptide - NP_001127910
RefSeq Peptide - NP_001127911
RefSeq Peptide - NP_665696
RefSeq Peptide - NP_001127909
swissprot - Q86SQ0
swissprot - E9PFQ4
swissprot - E9PDY7
swissprot - A0A1W2PRT1
swissprot - A0A1W2PRJ2
swissprot - A0A1W2PQ63
swissprot - G5E9V3
swissprot - E9PGF6
Ensembl - ENSG00000144824
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phldb2aENSDARG00000079889Danio rerio
 phldb2bENSDARG00000074843Danio rerio
 PHLDB2ENSGALG00000015377Gallus gallus
 Phldb2ENSMUSG00000033149Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PHLDB1 / Q86UU1 / pleckstrin homology like domain family B member 1ENSG0000001914437
PHLDB3 / Q6NSJ2 / pleckstrin homology like domain family B member 3ENSG0000017653118


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IMP
 biological_processGO:0010470 regulation of gastrulation IMP
 biological_processGO:0010717 regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0045184 establishment of protein localization IMP
 biological_processGO:0051497 negative regulation of stress fiber assembly IMP
 biological_processGO:0051895 negative regulation of focal adhesion assembly IMP
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IGI
 biological_processGO:1903690 negative regulation of wound healing, spreading of epidermal cells IMP
 biological_processGO:1904261 positive regulation of basement membrane assembly involved in embryonic body morphogenesis IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IDA
 cellular_componentGO:0045180 basal cortex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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