ENSG00000151876


Homo sapiens

Features
Gene ID: ENSG00000151876
  
Biological name :FBXO4
  
Synonyms : F-box protein 4 / FBXO4 / Q9UKT5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: p13.1
Gene start: 41925254
Gene end: 41941743
  
Corresponding Affymetrix probe sets: 220550_at (Human Genome U133 Plus 2.0 Array)   223493_at (Human Genome U133 Plus 2.0 Array)   233366_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000424991
Ensembl peptide - ENSP00000281623
Ensembl peptide - ENSP00000296812
Ensembl peptide - ENSP00000421749
Ensembl peptide - ENSP00000424750
NCBI entrez gene - 26272     See in Manteia.
OMIM - 609090
RefSeq - XM_011514027
RefSeq - NM_001297437
RefSeq - NM_012176
RefSeq - NM_033484
RefSeq - XM_006714470
RefSeq - XM_011514026
RefSeq Peptide - NP_277019
RefSeq Peptide - NP_036308
RefSeq Peptide - NP_001284366
swissprot - D6RAJ6
swissprot - D6RAU6
swissprot - D6REP2
swissprot - Q9UKT5
Ensembl - ENSG00000151876
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxo4ENSDARG00000074170Danio rerio
 FBXO4ENSGALG00000014851Gallus gallus
 Fbxo4ENSMUSG00000022184Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001810  F-box domain
 IPR036047  F-box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0007568 aging IEA
 biological_processGO:0010608 posttranscriptional regulation of gene expression IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0019725 cellular homeostasis IEA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0031398 positive regulation of protein ubiquitination IDA
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IMP
 biological_processGO:0035726 common myeloid progenitor cell proliferation IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0048147 negative regulation of fibroblast proliferation IEA
 biological_processGO:0071479 cellular response to ionizing radiation IEA
 biological_processGO:1900181 negative regulation of protein localization to nucleus IEA
 biological_processGO:1902916 positive regulation of protein polyubiquitination IEA
 biological_processGO:2000001 regulation of DNA damage checkpoint IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Association of TriC/CCT with target proteins during biosynthesis
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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