ENSG00000163874


Homo sapiens

Features
Gene ID: ENSG00000163874
  
Biological name :ZC3H12A
  
Synonyms : Q5D1E8 / ZC3H12A / zinc finger CCCH-type containing 12A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p34.3
Gene start: 37474552
Gene end: 37484379
  
Corresponding Affymetrix probe sets: 218810_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000492053
Ensembl peptide - ENSP00000362179
Ensembl peptide - ENSP00000473447
NCBI entrez gene - 80149     See in Manteia.
OMIM - 610562
RefSeq - XM_011542198
RefSeq - NM_001323550
RefSeq - NM_001323551
RefSeq - NM_025079
RefSeq Peptide - NP_001310479
RefSeq Peptide - NP_001310480
RefSeq Peptide - NP_079355
swissprot - Q5D1E8
swissprot - R4GN17
swissprot - A0A1W2PQC8
Ensembl - ENSG00000163874
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-206d17.12ENSDARG00000101034Danio rerio
 zc3h12aENSDARG00000005271Danio rerio
 ZC3H12AENSGALG00000002021Gallus gallus
 Q5D1E7ENSMUSG00000042677Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9C0D7 / ZC3H12C / zinc finger CCCH-type containing 12CENSG0000014928946
Q5HYM0 / ZC3H12B / zinc finger CCCH-type containing 12BENSG0000010205345
A2A288 / ZC3H12D / zinc finger CCCH-type containing 12DENSG0000017819938
KHNYN / O15037 / KH and NYN domain containingENSG0000010044122
N4BP1 / O75113 / NEDD4 binding protein 1ENSG0000010292122
NYNRIN / Q9P2P1 / NYN domain and retroviral integrase containingENSG0000020597821


Protein motifs (from Interpro)
Interpro ID Name
 IPR021869  Ribonuclease Zc3h12a-like, NYN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0002230 positive regulation of defense response to virus by host IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002757 immune response-activating signal transduction IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0010508 positive regulation of autophagy IDA
 biological_processGO:0010595 positive regulation of endothelial cell migration IDA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010656 negative regulation of muscle cell apoptotic process IEA
 biological_processGO:0010884 positive regulation of lipid storage IEA
 biological_processGO:0010942 positive regulation of cell death IDA
 biological_processGO:0016579 protein deubiquitination IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0032715 negative regulation of interleukin-6 production IDA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IDA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0042149 cellular response to glucose starvation IEA
 biological_processGO:0042307 positive regulation of protein import into nucleus IDA
 biological_processGO:0043031 negative regulation of macrophage activation IC
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0044828 negative regulation by host of viral genome replication IDA
 biological_processGO:0045019 negative regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050713 negative regulation of interleukin-1 beta secretion IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0051259 protein complex oligomerization IDA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0055118 negative regulation of cardiac muscle contraction IEA
 biological_processGO:0061014 positive regulation of mRNA catabolic process IEA
 biological_processGO:0061158 3"-UTR-mediated mRNA destabilization IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 biological_processGO:0090501 RNA phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 biological_processGO:0098586 cellular response to virus IDA
 biological_processGO:1900016 negative regulation of cytokine production involved in inflammatory response IEA
 biological_processGO:1900119 positive regulation of execution phase of apoptosis IEA
 biological_processGO:1900165 negative regulation of interleukin-6 secretion IEA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IDA
 biological_processGO:1902714 negative regulation of interferon-gamma secretion IEA
 biological_processGO:1903003 positive regulation of protein deubiquitination IMP
 biological_processGO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA IDA
 biological_processGO:1903936 cellular response to sodium arsenite IEA
 biological_processGO:1904468 negative regulation of tumor necrosis factor secretion IEA
 biological_processGO:1904637 cellular response to ionomycin IEA
 biological_processGO:1990869 cellular response to chemokine IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IDA
 biological_processGO:2000627 positive regulation of miRNA catabolic process IDA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005856 cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030867 rough endoplasmic reticulum membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IDA
 cellular_componentGO:0042406 extrinsic component of endoplasmic reticulum membrane IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0003730 mRNA 3"-UTR binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity IEA
 molecular_functionGO:0004532 exoribonuclease activity IEA
 molecular_functionGO:0004540 ribonuclease activity IDA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0035198 miRNA binding IDA
 molecular_functionGO:0035613 RNA stem-loop binding IEA
 molecular_functionGO:0035925 mRNA 3"-UTR AU-rich region binding IEA
 molecular_functionGO:0043022 ribosome binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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