ENSG00000164430


Homo sapiens

Features
Gene ID: ENSG00000164430
  
Biological name :CGAS
  
Synonyms : CGAS / cyclic GMP-AMP synthase / Q8N884
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q13
Gene start: 73413515
Gene end: 73452276
  
Corresponding Affymetrix probe sets: 1559051_s_at (Human Genome U133 Plus 2.0 Array)   1561708_at (Human Genome U133 Plus 2.0 Array)   242077_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000359339
Ensembl peptide - ENSP00000359342
NCBI entrez gene - 115004     See in Manteia.
OMIM - 613973
RefSeq - XM_017010232
RefSeq - NM_138441
RefSeq Peptide - NP_612450
swissprot - Q8N884
Ensembl - ENSG00000164430
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mb21d1ENSDARG00000021572Danio rerio
 ENSGALG00000015925Gallus gallus
 Mb21d1ENSMUSG00000032344Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024810  Mab-21 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002218 activation of innate immune response IEA
 biological_processGO:0002230 positive regulation of defense response to virus by host IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IDA
 biological_processGO:0032481 positive regulation of type I interferon production IEA
 biological_processGO:0038001 paracrine signaling IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0071360 cellular response to exogenous dsRNA IEA
 biological_processGO:2000774 positive regulation of cellular senescence IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061501 cyclic-GMP-AMP synthase activity IDA


Pathways (from Reactome)
Pathway description
STING mediated induction of host immune responses


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr