ENSG00000165730


Homo sapiens

Features
Gene ID: ENSG00000165730
  
Biological name :STOX1
  
Synonyms : Q6ZVD7 / storkhead box 1 / STOX1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q22.1
Gene start: 68827541
Gene end: 68895432
  
Corresponding Affymetrix probe sets: 1553202_at (Human Genome U133 Plus 2.0 Array)   229378_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000382118
Ensembl peptide - ENSP00000298596
Ensembl peptide - ENSP00000382115
Ensembl peptide - ENSP00000382121
Ensembl peptide - ENSP00000494558
NCBI entrez gene - 219736     See in Manteia.
OMIM - 609397
RefSeq - XM_011539454
RefSeq - NM_001130159
RefSeq - NM_001130160
RefSeq - NM_001130161
RefSeq - NM_152709
RefSeq Peptide - NP_001123632
RefSeq Peptide - NP_001123633
RefSeq Peptide - NP_689922
RefSeq Peptide - NP_001123631
swissprot - Q6ZVD7
Ensembl - ENSG00000165730
  
Related genetic diseases (OMIM): 609404 - Preeclampsia/eclampsia 4, 609404
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stox1ENSDARG00000062593Danio rerio
 Stox1ENSMUSG00000036923Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
STOX2 / Q9P2F5 / storkhead box 2ENSG0000017332023


Protein motifs (from Interpro)
Interpro ID Name
 IPR019391  Storkhead-box protein, winged-helix domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IMP
 biological_processGO:0010821 regulation of mitochondrion organization IMP
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IMP
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0045787 positive regulation of cell cycle IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051881 regulation of mitochondrial membrane potential IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia IMP
 biological_processGO:0071500 cellular response to nitrosative stress IMP
 biological_processGO:1901858 regulation of mitochondrial DNA metabolic process IMP
 biological_processGO:1902882 regulation of response to oxidative stress IMP
 biological_processGO:1904031 positive regulation of cyclin-dependent protein kinase activity IMP
 biological_processGO:1904120 positive regulation of otic vesicle morphogenesis IEA
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005938 cell cortex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0010982 Polygenic inheritance "A type of multifactorial inheritance governed by the simultaneous action of many (more than three) gene loci." [HPO:probinson, ISBN:978-0192628961]
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 HP:0100601 Ecplampsia "An acute and life-threatening complication of pregnancy, which is characterized by the appearance of tonic-clonic seizures, usually in a patient who had developed pre-eclampsia. Eclampsia includes seizures and coma that happen during pregnancy but are not due to preexisting or organic brain disorders." [HPO:sdoelken]
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 HP:0100602 Preecplampsia "Pregnancy-induced hypertension in association with significant amounts of protein in the urine." [HPO:sdoelken]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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