ENSG00000169188


Homo sapiens

Features
Gene ID: ENSG00000169188
  
Biological name :APEX2
  
Synonyms : APEX2 / apurinic/apyrimidinic endodeoxyribonuclease 2 / Q9UBZ4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: p11.21
Gene start: 55000357
Gene end: 55009057
  
Corresponding Affymetrix probe sets: 204408_at (Human Genome U133 Plus 2.0 Array)   238813_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000364126
NCBI entrez gene - 27301     See in Manteia.
OMIM - 300773
RefSeq - NM_001271748
RefSeq - NM_014481
RefSeq Peptide - NP_001258677
RefSeq Peptide - NP_055296
swissprot - Q9UBZ4
swissprot - E5KN95
Ensembl - ENSG00000169188
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apex2ENSDARG00000008472Danio rerio
 Apex2ENSMUSG00000025269Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
APEX1 / P27695 / apurinic/apyrimidinic endodeoxyribonuclease 1ENSG0000010082315


Protein motifs (from Interpro)
Interpro ID Name
 IPR004808  AP endonuclease 1
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR010666  Zinc finger, GRF-type
 IPR020847  AP endonuclease 1, binding site
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IBA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008311 double-stranded DNA 3"-5" exodeoxyribonuclease activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0140080 class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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