ENSG00000169248


Homo sapiens

Features
Gene ID: ENSG00000169248
  
Biological name :CXCL11
  
Synonyms : CXCL11 / C-X-C motif chemokine ligand 11 / O14625
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q21.1
Gene start: 76033682
Gene end: 76041415
  
Corresponding Affymetrix probe sets: 210163_at (Human Genome U133 Plus 2.0 Array)   211122_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000306884
Ensembl peptide - ENSP00000425819
NCBI entrez gene - 6373     See in Manteia.
OMIM - 604852
RefSeq - NM_001302123
RefSeq - NM_005409
RefSeq Peptide - NP_001289052
RefSeq Peptide - NP_005400
swissprot - O14625
Ensembl - ENSG00000169248
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 B0R191ENSDARG00000094706Danio rerio
 BX323596.2ENSDARG00000102514Danio rerio
 cxcl11.1ENSDARG00000100662Danio rerio
 CXCL11 (1 of many)ENSDARG00000101138Danio rerio
 cxcl11.5ENSDARG00000092423Danio rerio
 cxcl11.7ENSDARG00000093779Danio rerio
 cxcl11.8ENSDARG00000095747Danio rerio
 Cxcl11ENSMUSG00000060183Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001089  CXC chemokine
 IPR001811  Chemokine interleukin-8-like domain
 IPR018048  CXC chemokine, conserved site
 IPR027221  CXC chemokine 11
 IPR033899  CXC Chemokine domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002690 positive regulation of leukocyte chemotaxis IBA
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010818 T cell chemotaxis IMP
 biological_processGO:0030816 obsolete positive regulation of cAMP metabolic process IDA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IDA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IDA
 biological_processGO:0070098 chemokine-mediated signaling pathway IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008009 chemokine activity TAS
 molecular_functionGO:0008201 heparin binding IMP
 molecular_functionGO:0048248 CXCR3 chemokine receptor binding IDA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000186810 CXCR3 / P49682 / C-X-C motif chemokine receptor 3  / reaction / complex






 

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