ENSG00000169495


Homo sapiens

Features
Gene ID: ENSG00000169495
  
Biological name :HTRA4
  
Synonyms : HTRA4 / HtrA serine peptidase 4 / P83105
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p11.22
Gene start: 38974164
Gene end: 38988662
  
Corresponding Affymetrix probe sets: 1553706_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000305919
NCBI entrez gene - 203100     See in Manteia.
OMIM - 610700
RefSeq - NM_153692
RefSeq - XM_011544431
RefSeq Peptide - NP_710159
swissprot - P83105
Ensembl - ENSG00000169495
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htra4ENSDARG00000005943Danio rerio
 Htra4ENSMUSG00000037406Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HTRA1 / Q92743 / HtrA serine peptidase 1ENSG0000016603352
HTRA3 / P83110 / HtrA serine peptidase 3ENSG0000017080149
HTRA2 / O43464 / HtrA serine peptidase 2ENSG0000011531738


Protein motifs (from Interpro)
Interpro ID Name
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR001478  PDZ domain
 IPR001940  Peptidase S1C
 IPR002350  Kazal domain
 IPR009003  Peptidase S1, PA clan
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR036034  PDZ superfamily
 IPR036058  Kazal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0006508 proteolysis IDA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway ISS
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0004175 endopeptidase activity IDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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