ENSG00000172232


Homo sapiens

Features
Gene ID: ENSG00000172232
  
Biological name :AZU1
  
Synonyms : AZU1 / azurocidin 1 / P20160
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.3
Gene start: 825097
Gene end: 832018
  
Corresponding Affymetrix probe sets: 214575_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000233997
Ensembl peptide - ENSP00000481172
NCBI entrez gene - 566     See in Manteia.
OMIM - 162815
RefSeq - NM_001700
RefSeq Peptide - NP_001691
swissprot - A0A087WXP0
swissprot - P20160
Ensembl - ENSG00000172232
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ELANE / P08246 / elastase, neutrophil expressedENSG0000019756143
PRTN3 / P24158 / proteinase 3ENSG0000019641542


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001774 microglial cell activation IEP
 biological_processGO:0006508 proteolysis IDA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response NAS
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0008347 glial cell migration IDA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IDA
 biological_processGO:0019730 antimicrobial humoral response IMP
 biological_processGO:0035584 calcium-mediated signaling using intracellular calcium source IGI
 biological_processGO:0042117 monocyte activation TAS
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process IDA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0043066 negative regulation of apoptotic process NAS
 biological_processGO:0043114 regulation of vascular permeability NAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045123 cellular extravasation NAS
 biological_processGO:0045348 positive regulation of MHC class II biosynthetic process IEP
 biological_processGO:0045785 positive regulation of cell adhesion IDA
 biological_processGO:0045860 positive regulation of protein kinase activity IDA
 biological_processGO:0048246 macrophage chemotaxis NAS
 biological_processGO:0050725 positive regulation of interleukin-1 beta biosynthetic process IDA
 biological_processGO:0050754 positive regulation of fractalkine biosynthetic process IDA
 biological_processGO:0050766 positive regulation of phagocytosis IDA
 biological_processGO:0050829 defense response to Gram-negative bacterium TAS
 biological_processGO:0050930 induction of positive chemotaxis NAS
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0060326 cell chemotaxis IMP
 biological_processGO:0070528 protein kinase C signaling IMP
 biological_processGO:0070944 neutrophil mediated killing of bacterium IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane IDA
 cellular_componentGO:0035577 azurophil granule membrane IDA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0042582 azurophil granule IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IMP
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0015643 toxic substance binding NAS
 molecular_functionGO:0043395 heparan sulfate proteoglycan binding IDA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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