ENSG00000173404


Homo sapiens

Features
Gene ID: ENSG00000173404
  
Biological name :INSM1
  
Synonyms : INSM1 / INSM transcriptional repressor 1 / Q01101
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: p11.23
Gene start: 20368121
Gene end: 20370949
  
Corresponding Affymetrix probe sets: 206502_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000312631
NCBI entrez gene - 3642     See in Manteia.
OMIM - 600010
RefSeq - NM_002196
RefSeq Peptide - NP_002187
swissprot - Q01101
Ensembl - ENSG00000173404
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Insm1ENSMUSG00000068154Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
INSM2 / Q96T92 / INSM transcriptional repressor 2ENSG0000016834845


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001933 negative regulation of protein phosphorylation IDA
 biological_processGO:0003309 type B pancreatic cell differentiation IEA
 biological_processGO:0003310 pancreatic A cell differentiation IEA
 biological_processGO:0003323 type B pancreatic cell development IEA
 biological_processGO:0003358 noradrenergic neuron development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031018 endocrine pancreas development IEA
 biological_processGO:0035270 endocrine system development IEA
 biological_processGO:0042421 norepinephrine biosynthetic process IEA
 biological_processGO:0043254 regulation of protein complex assembly IDA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0060290 transdifferentiation IDA
 biological_processGO:0061104 adrenal chromaffin cell differentiation IEA
 biological_processGO:0061549 sympathetic ganglion development IEA
 biological_processGO:0071158 positive regulation of cell cycle arrest IDA
 biological_processGO:2000179 positive regulation of neural precursor cell proliferation IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0017053 transcriptional repressor complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0030332 cyclin binding IPI
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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