ENSG00000174989


Homo sapiens

Features
Gene ID: ENSG00000174989
  
Biological name :FBXW8
  
Synonyms : F-box and WD repeat domain containing 8 / FBXW8 / Q8N3Y1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.22
Gene start: 116910956
Gene end: 117031148
  
Corresponding Affymetrix probe sets: 231883_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000310686
Ensembl peptide - ENSP00000389144
NCBI entrez gene - 26259     See in Manteia.
OMIM - 609073
RefSeq - XM_017019177
RefSeq - NM_012174
RefSeq - NM_153348
RefSeq - XM_005253868
RefSeq - XM_017019175
RefSeq - XM_017019176
RefSeq - XM_005253867
RefSeq Peptide - NP_699179
RefSeq Peptide - NP_036306
swissprot - Q8N3Y1
Ensembl - ENSG00000174989
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxw8ENSDARG00000079089Danio rerio
 FBXW8ENSGALG00000008207Gallus gallus
 Fbxw8ENSMUSG00000032867Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR001810  F-box domain
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036047  F-box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0007030 Golgi organization ISS
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0050775 positive regulation of dendrite morphogenesis ISS
 biological_processGO:0060712 spongiotrophoblast layer development IEA
 biological_processGO:0060716 labyrinthine layer blood vessel development IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IEA
 cellular_componentGO:0031467 Cul7-RING ubiquitin ligase complex IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:1990393 3M complex IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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