ENSG00000178921


Homo sapiens

Features
Gene ID: ENSG00000178921
  
Biological name :PFAS
  
Synonyms : O15067 / PFAS / phosphoribosylformylglycinamidine synthase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p13.1
Gene start: 8247618
Gene end: 8270491
  
Corresponding Affymetrix probe sets: 213302_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000487260
Ensembl peptide - ENSP00000464671
Ensembl peptide - ENSP00000464689
Ensembl peptide - ENSP00000313490
Ensembl peptide - ENSP00000443244
Ensembl peptide - ENSP00000462874
Ensembl peptide - ENSP00000463045
Ensembl peptide - ENSP00000463103
Ensembl peptide - ENSP00000463362
NCBI entrez gene - 5198     See in Manteia.
OMIM - 602133
RefSeq - XM_017024760
RefSeq - NM_012393
RefSeq - XM_006721546
RefSeq Peptide - NP_036525
swissprot - J3QL39
swissprot - J3QSG0
swissprot - J3QSH6
swissprot - H0YGH1
swissprot - O15067
swissprot - J3KT98
swissprot - J3KTQ5
swissprot - J3KTL4
Ensembl - ENSG00000178921
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pfasENSDARG00000003750Danio rerio
 PfasENSMUSG00000020899Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR010073  Phosphoribosylformylglycinamidine synthase
 IPR010918  PurM-like, C-terminal domain
 IPR017926  Glutamine amidotransferase
 IPR029062  Class I glutamine amidotransferase-like
 IPR036604  Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily
 IPR036676  PurM-like, C-terminal domain superfamily
 IPR036921  PurM-like, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006164 purine nucleotide biosynthetic process IEA
 biological_processGO:0006189 "de novo" IMP biosynthetic process NAS
 biological_processGO:0006541 glutamine metabolic process IEA
 biological_processGO:0009156 ribonucleoside monophosphate biosynthetic process IEA
 biological_processGO:0009168 purine ribonucleoside monophosphate biosynthetic process TAS
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0097065 anterior head development IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004642 phosphoribosylformylglycinamidine synthase activity TAS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Purine ribonucleoside monophosphate biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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