ENSG00000185043


Homo sapiens

Features
Gene ID: ENSG00000185043
  
Biological name :CIB1
  
Synonyms : calcium and integrin binding 1 / CIB1 / Q99828
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q26.1
Gene start: 90229975
Gene end: 90234047
  
Corresponding Affymetrix probe sets: 201953_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000479860
Ensembl peptide - ENSP00000333873
NCBI entrez gene - 10519     See in Manteia.
OMIM - 602293
RefSeq - XM_006720375
RefSeq - NM_001277764
RefSeq - NM_006384
RefSeq Peptide - NP_001264693
RefSeq Peptide - NP_006375
swissprot - Q99828
swissprot - A0A140VK09
Ensembl - ENSG00000185043
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cib1ENSDARG00000103118Danio rerio
 CIB1ENSGALG00000008302Gallus gallus
 Cib1ENSMUSG00000030538Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CIB4 / A0PJX0 / calcium and integrin binding family member 4ENSG0000015788434
CIB3 / Q96Q77 / calcium and integrin binding family member 3ENSG0000014197732
CIB2 / O75838 / calcium and integrin binding family member 2ENSG0000013642529


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IEA
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0006302 double-strand break repair TAS
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0007026 negative regulation of microtubule depolymerization IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007113 endomitotic cell cycle IDA
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007286 spermatid development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010977 negative regulation of neuron projection development IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030220 platelet formation IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031122 cytoplasmic microtubule organization IMP
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin IDA
 biological_processGO:0038163 thrombopoietin-mediated signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0045653 negative regulation of megakaryocyte differentiation IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051302 regulation of cell division IMP
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070886 positive regulation of calcineurin-NFAT signaling cascade IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IMP
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:0090314 positive regulation of protein targeting to membrane IMP
 biological_processGO:0097191 extrinsic apoptotic signaling pathway TAS
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IDA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IDA
 biological_processGO:2000256 positive regulation of male germ cell proliferation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IMP
 cellular_componentGO:0005737 cytoplasm IMP
 cellular_componentGO:0005783 endoplasmic reticulum IMP
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031982 vesicle HDA
 cellular_componentGO:0032433 filopodium tip IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042383 sarcolemma IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0005509 calcium ion binding IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008427 calcium-dependent protein kinase inhibitor activity IMP
 molecular_functionGO:0017016 Ras GTPase binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030291 protein serine/threonine kinase inhibitor activity IDA
 molecular_functionGO:0043495 protein membrane anchor IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr