ENSG00000185686


Homo sapiens

Features
Gene ID: ENSG00000185686
  
Biological name :PRAME
  
Synonyms : P78395 / PRAME / preferentially expressed antigen in melanoma
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q11.22
Gene start: 22547701
Gene end: 22559361
  
Corresponding Affymetrix probe sets: 204086_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000385198
Ensembl peptide - ENSP00000385091
Ensembl peptide - ENSP00000399816
Ensembl peptide - ENSP00000445675
Ensembl peptide - ENSP00000412318
Ensembl peptide - ENSP00000407320
Ensembl peptide - ENSP00000407121
Ensembl peptide - ENSP00000381726
Ensembl peptide - ENSP00000381728
Ensembl peptide - ENSP00000384058
Ensembl peptide - ENSP00000384343
NCBI entrez gene - 23532     See in Manteia.
OMIM - 606021
RefSeq - NM_206953
RefSeq - NM_001291715
RefSeq - NM_001291716
RefSeq - NM_001291717
RefSeq - NM_001291719
RefSeq - NM_001318126
RefSeq - NM_001318127
RefSeq - NM_006115
RefSeq - NM_206954
RefSeq - NM_206955
RefSeq - NM_206956
RefSeq - XM_011530034
RefSeq Peptide - NP_996836
RefSeq Peptide - NP_996837
RefSeq Peptide - NP_996839
RefSeq Peptide - NP_001278644
RefSeq Peptide - NP_001278645
RefSeq Peptide - NP_001278646
RefSeq Peptide - NP_001278648
RefSeq Peptide - NP_001305055
RefSeq Peptide - NP_001305056
RefSeq Peptide - NP_006106
RefSeq Peptide - NP_996838
swissprot - A0A024R1E6
swissprot - B5MD04
swissprot - B5MCY4
swissprot - P78395
swissprot - F8WF80
swissprot - H7C2P3
swissprot - E7EW99
swissprot - E7EMH2
Ensembl - ENSG00000185686
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O95522 / PRAMEF12 / PRAME family member 12ENSG0000011672650
Q5VWM4 / PRAMEF8 / PRAME family member 8ENSG0000018233049
Q5VXH5 / PRAMEF7 / PRAME family member 7ENSG0000020451049
Q5VXH4 / PRAMEF6 / PRAME family member 6ENSG0000023242348
PRAMEF11 / PRAME family member 11ENSG0000023981048
A6NGN4 / PRAMEF25 / PRAME family member 25ENSG0000022957148
A3QJZ7 / PRAMEF27 / PRAME family member 27ENSG0000027476448
O60810 / PRAMEF4 / PRAME family member 4ENSG0000024307348
PRAMEF26 / PRAME family member 26ENSG0000028026748
Q5TYX0 / PRAMEF5 / PRAME family member 5ENSG0000027060148
PRAMEF9 / PRAME family member 9ENSG0000020450548
Q5VWM5 / PRAMEF15 / PRAME family member 15ENSG0000020450148
Q5VT98 / PRAMEF20 / PRAME family member 20ENSG0000020447848
Q5VWM3 / PRAMEF18 / PRAME family member 18ENSG0000027980443
PRAMEF14 / PRAME family member 14ENSG0000020448142
O95521 / PRAMEF1 / PRAME family member 1ENSG0000011672142
O60809 / PRAMEF10 / PRAME family member 10ENSG0000018754541
Q5VTA0 / PRAMEF17 / PRAME family member 17ENSG0000020447941
PRAMEF33 / A0A0G2JMD5 / PRAME family member 33ENSG0000023770041
O60811 / PRAMEF2 / PRAME family member 2ENSG0000012095241


Protein motifs (from Interpro)
Interpro ID Name
 IPR026271  PRAME family
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0045596 negative regulation of cell differentiation IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0048387 negative regulation of retinoic acid receptor signaling pathway IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042974 retinoic acid receptor binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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