ENSG00000186815


Homo sapiens

Features
Gene ID: ENSG00000186815
  
Biological name :TPCN1
  
Synonyms : Q9ULQ1 / TPCN1 / two pore segment channel 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.13
Gene start: 113221050
Gene end: 113298585
  
Corresponding Affymetrix probe sets: 1557185_at (Human Genome U133 Plus 2.0 Array)   1557186_s_at (Human Genome U133 Plus 2.0 Array)   217914_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449564
Ensembl peptide - ENSP00000449560
Ensembl peptide - ENSP00000449944
Ensembl peptide - ENSP00000335300
Ensembl peptide - ENSP00000376350
Ensembl peptide - ENSP00000438125
Ensembl peptide - ENSP00000446767
Ensembl peptide - ENSP00000447073
Ensembl peptide - ENSP00000447181
Ensembl peptide - ENSP00000447263
Ensembl peptide - ENSP00000447569
Ensembl peptide - ENSP00000447806
Ensembl peptide - ENSP00000448010
Ensembl peptide - ENSP00000448083
Ensembl peptide - ENSP00000448561
Ensembl peptide - ENSP00000448704
NCBI entrez gene - 53373     See in Manteia.
OMIM - 609666
RefSeq - XM_017019482
RefSeq - NM_001143819
RefSeq - NM_001301214
RefSeq - NM_001351347
RefSeq - NM_017901
RefSeq - XM_005253906
RefSeq - XM_011538490
RefSeq - XM_011538492
RefSeq - XM_011538493
RefSeq - XM_017019480
RefSeq - XM_017019481
RefSeq Peptide - NP_001338276
RefSeq Peptide - NP_060371
RefSeq Peptide - NP_001137291
RefSeq Peptide - NP_001288143
RefSeq Peptide - NP_001338275
swissprot - F8VV93
swissprot - F8VVY9
swissprot - F8VZZ6
swissprot - F8W0K7
swissprot - F8W0P9
swissprot - F8W1G4
swissprot - F8W1L6
swissprot - H0YIK4
swissprot - H0YHX1
swissprot - Q9ULQ1
swissprot - B7Z3R2
swissprot - F8VR74
swissprot - F8VS97
Ensembl - ENSG00000186815
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tpcn1ENSDARG00000062362Danio rerio
 TPCN1ENSGALG00000008357Gallus gallus
 Tpcn1ENSMUSG00000032741Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TPCN2 / Q8NHX9 / two pore segment channel 2ENSG0000016234119


Protein motifs (from Interpro)
Interpro ID Name
 IPR005821  Ion transport domain
 IPR028746  Cation channel sperm-associated protein 1
 IPR028801  Two pore calcium channel protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0010508 positive regulation of autophagy IDA
 biological_processGO:0030317 flagellated sperm motility IEA
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0086010 membrane depolarization during action potential IBA
 cellular_componentGO:0005764 lysosome TAS
 cellular_componentGO:0005765 lysosomal membrane TAS
 cellular_componentGO:0005768 endosome TAS
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0036128 CatSper complex IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005227 calcium activated cation channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0072345 NAADP-sensitive calcium-release channel activity TAS


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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