ENSG00000214357


Homo sapiens

Features
Gene ID: ENSG00000214357
  
Biological name :NEURL1B
  
Synonyms : A8MQ27 / neuralized E3 ubiquitin protein ligase 1B / NEURL1B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q35.1
Gene start: 172641266
Gene end: 172691540
  
Corresponding Affymetrix probe sets: 225355_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000430001
Ensembl peptide - ENSP00000358815
Ensembl peptide - ENSP00000429797
NCBI entrez gene - 54492     See in Manteia.
OMIM - 615893
RefSeq - NM_001142651
RefSeq - NM_001308177
RefSeq - NM_001308178
RefSeq Peptide - NP_001295107
RefSeq Peptide - NP_001136123
RefSeq Peptide - NP_001295106
swissprot - A8MQ27
Ensembl - ENSG00000214357
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 neurl1bENSDARG00000099694Danio rerio
 ENSGALG00000002846Gallus gallus
 Q0MW30ENSMUSG00000034413Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NEURL1 / O76050 / neuralized E3 ubiquitin protein ligase 1ENSG0000010795441
NEURL3 / Q96EH8 / neuralized E3 ubiquitin protein ligase 3ENSG0000016312118


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR006573  Neuralized homology repeat (NHR) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0070086 ubiquitin-dependent endocytosis IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005769 early endosome IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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