ENSG00000236637


Homo sapiens

Features
Gene ID: ENSG00000236637
  
Biological name :IFNA4
  
Synonyms : IFNA4 / interferon alpha 4 / P05014
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: p21.3
Gene start: 21186694
Gene end: 21187671
  
Corresponding Affymetrix probe sets: 207964_x_at (Human Genome U133 Plus 2.0 Array)   208261_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000412897
NCBI entrez gene - 3441     See in Manteia.
OMIM - 147564
RefSeq - NM_021068
RefSeq Peptide - NP_066546
swissprot - P05014
Ensembl - ENSG00000236637
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000015062Gallus gallus
 Ifna1ENSMUSG00000095498Mus musculus
 Ifna11ENSMUSG00000100549Mus musculus
 Ifna12ENSMUSG00000073811Mus musculus
 Ifna13ENSMUSG00000063376Mus musculus
 Ifna14ENSMUSG00000095896Mus musculus
 Ifna15ENSMUSG00000096011Mus musculus
 Ifna16ENSMUSG00000078355Mus musculus
 Ifna2ENSMUSG00000078354Mus musculus
 Ifna4ENSMUSG00000070904Mus musculus
 Ifna5ENSMUSG00000096682Mus musculus
 Ifna6ENSMUSG00000101252Mus musculus
 Ifna7ENSMUSG00000100713Mus musculus
 Ifna9ENSMUSG00000095270Mus musculus
 IfnabENSMUSG00000100079Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IFNA17 / P01571 / interferon alpha 17ENSG0000023482996
IFNA10 / P01566 / interferon alpha 10ENSG0000018680396
IFNA7 / P01567 / interferon alpha 7ENSG0000021404294
IFNA21 / P01568 / interferon alpha 21ENSG0000013708092
IFNA16 / P05015 / interferon alpha 16ENSG0000014788589
IFNA5 / P01569 / interferon alpha 5ENSG0000014787384
IFNA14 / P01570 / interferon alpha 14ENSG0000022808384
IFNA8 / P32881 / interferon alpha 8ENSG0000012024281
IFNA6 / P05013 / interferon alpha 6ENSG0000012023581
IFNA2 / P01563 / interferon alpha 2ENSG0000018837981
IFNA1 / P01562 / interferon alpha 1ENSG0000019791980
IFNA13 / P01562 / interferon alpha 13ENSG0000023381680
IFNW1 / P05000 / interferon omega 1ENSG0000017704758
IFNK / Q9P0W0 / interferon kappaENSG0000014789630


Protein motifs (from Interpro)
Interpro ID Name
 IPR000471  Interferon alpha/beta/delta
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IBA
 biological_processGO:0002286 T cell activation involved in immune response IBA
 biological_processGO:0002323 natural killer cell activation involved in immune response IBA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006959 humoral immune response IBA
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0009615 response to virus TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0030183 B cell differentiation IBA
 biological_processGO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein IBA
 biological_processGO:0042100 B cell proliferation IBA
 biological_processGO:0043330 response to exogenous dsRNA IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060337 type I interferon signaling pathway TAS
 biological_processGO:0060338 regulation of type I interferon-mediated signaling pathway TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005126 cytokine receptor binding IEA
 molecular_functionGO:0005132 type I interferon receptor binding TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Interferon alpha/beta signaling
Regulation of IFNA signaling
TRAF6 mediated IRF7 activation
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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