ENSG00000277399


Homo sapiens

Features
Gene ID: ENSG00000277399
  
Biological name :GPR179
  
Synonyms : GPR179 / G protein-coupled receptor 179
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q12
Gene start: 38325530
Gene end: 38343847
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000480024
Ensembl peptide - ENSP00000483469
NCBI entrez gene - 440435     See in Manteia.
OMIM - 614515
RefSeq - NM_001004334
RefSeq Peptide - NP_001004334
swissprot - A0A087X0K8
swissprot - A0A087WW83
Ensembl - ENSG00000277399
  
Related genetic diseases (OMIM): 614565 - Night blindness, congenital stationary (complete), 1E, autosomal recessive, 614565
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-156l18.8ENSDARG00000102310Danio rerio
 ENSGALG00000037179Gallus gallus
 Gpr179ENSMUSG00000070337Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GPR158 / Q5T848 / G protein-coupled receptor 158ENSG0000015102519


Protein motifs (from Interpro)
Interpro ID Name
 IPR017978  GPCR family 3, C-terminal
 IPR032964  Probable G-protein coupled receptor 179


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0044292 dendrite terminus IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000486 Strabismus "Strabismus (also known as squint) is a condition in which the eyes are not properly aligned with each other." [HPO:curators]
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 HP:0000505 Impaired vision 
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 HP:0000545 Myopia 
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 HP:0000639 Nystagmus "Rhythmic, involuntary oscillations of one or both eyes related to abnormality in fixation, conjugate gaze, or vestibular mechanisms." [HPO:curators]
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 HP:0000662 Night blindness 
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 HP:0001419 X-linked recessive inheritance "A mode of inheritance that is observed for recessive traits related to a gene encoded on the X chromosome. In the context of medical genetics, X-linked recessive disorders manifest in males (who have one copy of the X chromosome and are thus hemizygotes), but generally not in female heterozygotes who have one mutant and one normal allele." [HPO:curators]
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 HP:0007642 Congenital stationary night blindness 
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 HP:0007663 Decreased central vision 
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 HP:0007766 Hypoplastic optic disks 
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 HP:0008002 Macular pigmentary changes 
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 HP:0011003 Severe Myopia 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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