ENSGALG00000008108


Gallus gallus

Features
Gene ID: ENSGALG00000008108
  
Biological name :PSMC3
  
Synonyms : proteasome 26S subunit, ATPase 3 / PSMC3
  
Possible biological names infered from orthology : O88685 / P17980 / proteasome (prosome, macropain) 26S subunit, ATPase 3
  
Species: Gallus gallus
  
Chr. number: 5
Strand: 1
Band:
Gene start: 22872406
Gene end: 22883540
  
Corresponding Affymetrix probe sets: Gga.4649.1.S1_s_at (Chicken Array)   Gga.6823.1.A1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000037708
NCBI entrez gene - 423182     See in Manteia.
RefSeq - NM_001031190
RefSeq Peptide - NP_001026361
swissprot - Q5ZIT7
Ensembl - ENSGALG00000008108
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmc3ENSDARG00000007141Danio rerio
 PSMC3ENSG00000165916Homo sapiens
 Psmc3ENSMUSG00000002102Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR005937  26S proteasome regulatory subunit P45-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001824 blastocyst development IEA
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IBA
 biological_processGO:0043921 modulation by host of viral transcription IEA
 biological_processGO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process IEA
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0008540 proteasome regulatory particle, base subcomplex IBA
 cellular_componentGO:0022624 proteasome accessory complex IEA
 cellular_componentGO:0031595 nuclear proteasome complex IBA
 cellular_componentGO:0031597 cytosolic proteasome complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017025 TBP-class protein binding IBA
 molecular_functionGO:0036402 proteasome-activating ATPase activity IBA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr