ENSGALG00000027864


Gallus gallus

Features
Gene ID: ENSGALG00000027864
  
Biological name :NFKBIA
  
Synonyms : NF-kappa-B inhibitor alpha / NFKBIA
  
Possible biological names infered from orthology : NFKB inhibitor alpha / P25963 / Q9Z1E3
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 36236931
Gene end: 36240449
  
Corresponding Affymetrix probe sets: GgaAffx.1.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000041417
NCBI entrez gene - 396093     See in Manteia.
RefSeq - NM_001001472
RefSeq Peptide - NP_001001472
swissprot - R4GH80
Ensembl - ENSGALG00000027864
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfkbiaaENSDARG00000005481Danio rerio
 nfkbiabENSDARG00000007693Danio rerio
 NFKBIAENSG00000100906Homo sapiens
 NfkbiaENSMUSG00000021025Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NFKBIE / NFKB inhibitor epsilon / O00221* / O54910* / NF-kappa-B inhibitor epsilon *ENSGALG0000004452531
NFKBIB / NFKB inhibitor beta / Q15653* / Q60778* / NF-kappa-B inhibitor beta *ENSGALG0000002969127
NFKBIZ / NF-kappa-B inhibitor zeta / Q9BYH8* / Q9EST8* / NFKB inhibitor zeta*ENSGALG0000001534621
ENSGALG0000004525114
NFKBID* / Q2TB02* / Q8NI38* / NFKB inhibitor delta* / NF-kappa-B inhibitor delta *ENSGALG000000284967


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0007253 cytoplasmic sequestering of NF-kappaB IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010745 negative regulation of macrophage derived foam cell differentiation IEA
 biological_processGO:0010875 positive regulation of cholesterol efflux IEA
 biological_processGO:0010888 negative regulation of lipid storage IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IEA
 biological_processGO:0032495 response to muramyl dipeptide IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0034142 toll-like receptor 4 signaling pathway IEA
 biological_processGO:0035994 response to muscle stretch IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042994 cytoplasmic sequestering of transcription factor IEA
 biological_processGO:0043330 response to exogenous dsRNA IEA
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IEA
 biological_processGO:0045746 negative regulation of Notch signaling pathway IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway IEA
 biological_processGO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0008139 nuclear localization sequence binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0051059 NF-kappaB binding IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Downstream TCR signaling
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
SUMOylation of immune response proteins
CLEC7A (Dectin-1) signaling
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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