ENSGALG00000039387


Gallus gallus

Features
Gene ID: ENSGALG00000039387
  
Biological name :PSMA2
  
Synonyms : proteasome subunit alpha 2 / PSMA2
  
Possible biological names infered from orthology : P25787 / P49722 / Proteasome subunit alpha type-2
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 51323804
Gene end: 51330367
  
Corresponding Affymetrix probe sets: GgaAffx.13122.1.S1_at (Chicken Array)   GgaAffx.13122.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050972
Ensembl peptide - ENSGALP00000062451
Ensembl peptide - ENSGALP00000061282
Ensembl peptide - ENSGALP00000059806
Ensembl peptide - ENSGALP00000052572
Ensembl peptide - ENSGALP00000052290
NCBI entrez gene - 420772     See in Manteia.
RefSeq - NM_001012860
RefSeq Peptide - NP_001012878
swissprot - A0A1D5PID9
swissprot - A0A1L1RUE8
swissprot - A0A1D5PDX4
swissprot - A0A1D5PHL0
swissprot - A0A1L1RM01
Ensembl - ENSGALG00000039387
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psma2ENSDARG00000040121Danio rerio
 si:rp71-45k5.4ENSDARG00000035679Danio rerio
 PSMA2ENSG00000106588Homo sapiens
 Psma2ENSMUSG00000015671Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000426  Proteasome alpha-subunit, N-terminal domain
 IPR001353  Proteasome, subunit alpha/beta
 IPR023332  Proteasome alpha-type subunit
 IPR029055  Nucleophile aminohydrolases, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IEA
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005839 proteasome core complex IEA
 cellular_componentGO:0019773 proteasome core complex, alpha-subunit complex IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004298 threonine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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