ENSMUSG00000000282


Mus musculus

Features
Gene ID: ENSMUSG00000000282
  
Biological name :Mnt
  
Synonyms : Max-binding protein MNT / Mnt / O08789
  
Possible biological names infered from orthology : MAX network transcriptional repressor / Q99583
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 74830920
Gene end: 74845725
  
Corresponding Affymetrix probe sets: 10378497 (MoGene1.0st)   1418192_at (Mouse Genome 430 2.0 Array)   1418193_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000291
Ensembl peptide - ENSMUSP00000118435
NCBI entrez gene - 17428     See in Manteia.
MGI - MGI:109150
RefSeq - XM_006532402
RefSeq - NM_010813
RefSeq Peptide - NP_034943
swissprot - O08789
swissprot - Q5SWE2
Ensembl - ENSMUSG00000000282
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mntaENSDARG00000101859Danio rerio
 mntbENSDARG00000073988Danio rerio
 MNTENSGALG00000005830Gallus gallus
 MNTENSG00000070444Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0007569 cell aging IMP
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Mnttm1.1Awb/Mnttm1.1Awb
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
Show

Allelic Composition: Meox2fla/Meox2fla
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Bdnftm1Sieg/Bdnftm1Sieg,Tg(Camk2a-cre)3Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Bdnftm1Sieg/Bdnftm1Sieg,Tg(Camk2a-cre)3Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mnttm1.1Awb/Mnttm1.1Awb
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
Show

Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

Allelic Composition: Mnttm1Awb/Mnttm1.1Awb,Tg(MMTV-cre)4Mam/?
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mnttm1.1Awb/Mnttm1.1Awb
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0004384 small interparietal bone "reduced size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mnttm1.1Awb/Mnttm1.1Awb
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0004441 small occipital bone "reduced size of the bone at the lower, posterior part of the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Mnttm1.1Awb/Mnttm1.1Awb
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0004476 absent palatine bone "absence of either of two irregularly shaped bones that form the back of the hard palate and helps to form the nasal cavity and the floor of the orbits" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Mnttm1.1Awb/Mnttm1.1Awb
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0004592 small mandible "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Mnttm1.1Awb/Mnttm1.1Awb
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005274 abnormal viscerocranium morphology "anomalous structure or formation of the part of the skull that comprises the facial bones " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mnttm1.1Awb/Mnttm1.1Awb
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mnttm1.1Awb/Mnttm1.1Awb
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bdnftm1Sieg/Bdnftm1Sieg,Tg(Camk2a-cre)3Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mnttm1Awb/Mnttm1.1Awb,Tg(MMTV-cre)4Mam/?
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mnttm1.1Awb/Mnttm1.1Awb
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mnttm1.1Awb/Mnttm1.1Awb
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
Show

Allelic Composition: Mnttm1.1Awb/Mnttm1.1Awb
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Bdnftm1Sieg/Bdnftm1Sieg,Tg(Camk2a-cre)3Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Mnttm1.1Awb/Mnttm1.1Awb
Genetic Background: involves: 129S6/SvEvTac * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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