| MP:0000260 | abnormal angiogenesis | "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cd86tm1Shr/Cd86tm1Shr
Genetic Background: B6.129S4-Cd86tm1Shr
|
| MP:0000267 | abnormal cardiac development | "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370] |
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Allelic Composition: Cd86tm1Shr/Cd86tm1Shr
Genetic Background: B6.129S4-Cd86tm1Shr
Allelic Composition: Ccm2tm2.1Sbn/Ccm2tm2.1Sbn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0000270 | abnormal heart tube morphology | "malformed embryonic heart " [J:37888] |
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Allelic Composition: Pax6m1Lsli/Pax6+
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0000274 | enlarged heart | "increase over normal size of the heart" [J:29971] |
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Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Ccm2tm1Etl Tg(Tek-cre)1Ywa
|
| MP:0000280 | thin ventricular wall | "decreased depth of the cardiac wall of the heart ventricles" [J:45302] |
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Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Ccm2tm1Etl Tg(Tek-cre)1Ywa
|
| MP:0000297 | abnormal endocardial cushion morphology | "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Ccm2tm1Etl Tg(Tek-cre)1Ywa
|
| MP:0000820 | abnormal choroid plexus morphology | "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302] |
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Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Ccm2tm1Etl Tg(Tek-cre)1Ywa
|
| MP:0000849 | abnormal cerebellum morphology | "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
|
| MP:0001393 | ataxia | "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231] |
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Allelic Composition: Ccm2tm2.1Sbn/Ccm2tm2.1Sbn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0001622 | abnormal vasculogenesis | "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex,Usp1tm1.1Ada/Usp1tm1.1Ada
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0001633 | poor circulation | "insufficient movement of blood throughout the body" [MGI:cls, J:45302] |
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Allelic Composition: Apptm1Somm/Apptm1Somm
Genetic Background: C57BL/6-Apptm1Somm
Allelic Composition: Ccm2tm1.1Kwhi/Ccm2tm1.1Kwhi
Genetic Background: involves: C57BL/6
Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1.1Kwhi,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0001688 | abnormal somite development | "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ccm2tm1.1Etl/Ccm2tm1.1Etl
Genetic Background: B6.129-Ccm2tm1.1Etl
|
| MP:0001719 | absent vitelline blood vessels | "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623] |
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Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Ccm2tm1Etl Tg(Tek-cre)1Ywa
|
| MP:0001722 | pale yolk sac | "bloodless yolk sac" [J:62571] |
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Allelic Composition: Pax6m1Lsli/Pax6+
Genetic Background: involves: C3H/HeJ * C57BL/6J
Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Ccm2tm1Etl Tg(Tek-cre)1Ywa
|
| MP:0001730 | embryonic growth arrest | "the cessation of development beyond a particular stage" [J:17509] |
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Allelic Composition: Ccm2tm1.1Etl/Ccm2tm1.1Etl
Genetic Background: B6.129-Ccm2tm1.1Etl
|
| MP:0001787 | pericardial edema | "accumulation of watery fluid in the pericardial sac of the heart" [J:52597] |
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Allelic Composition: Pax6m1Lsli/Pax6+
Genetic Background: involves: C3H/HeJ * C57BL/6J
Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Ccm2tm1Etl Tg(Tek-cre)1Ywa
Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2+,Heg1tm1Mlkn/Heg1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Ccm2tm1Sbn/Ccm2tm1Sbn
Genetic Background: involves: C57BL/6
|
| MP:0001915 | intracranial hemorrhage | "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Apptm1Somm/Apptm1Somm
Genetic Background: C57BL/6-Apptm1Somm
Allelic Composition: Ccm2tm2.1Sbn/Ccm2tm2.1Sbn,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0001916 | intracerebral hemorrhage | "bleeding within the cerebrum" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ccm2tm2.1Sbn/Ccm2tm2.1Sbn,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0002064 | seizures | "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ccm2tm2.1Sbn/Ccm2tm2.1Sbn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0002082 | postnatal lethality | "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1Kwhi,Tg(Nes-cre)1Kln/?
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ccm2tm2.1Sbn/Ccm2tm2.1Sbn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0002127 | abnormal cardiovascular system morphology | "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Apptm1Somm/Apptm1Somm
Genetic Background: C57BL/6-Apptm1Somm
Allelic Composition: Ccm2tm1.1Kwhi/Ccm2tm1.1Kwhi
Genetic Background: involves: C57BL/6
Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1.1Kwhi,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ccm2tm1.1Etl/Ccm2tm1.1Etl
Genetic Background: B6.129-Ccm2tm1.1Etl
Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1.1Kwhi,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1.1Kwhi,Tg(Tagln-cre)1Jjl/0
Genetic Background: involves: FVB/N
Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1Kwhi,Tg(Nes-cre)1Kln/?
Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2Gt(RRG051)Byg/Ccm2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6
|
| MP:0002182 | abnormal astrocyte morphology | "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1Kwhi,Tg(Nes-cre)1Kln/?
Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Ccm2tm2.1Sbn/Ccm2tm2.1Sbn,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0002582 | disorganized extraembryonic tissue | "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Ccm2tm1Etl Tg(Tek-cre)1Ywa
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| MP:0002672 | abnormal branchial arch artery morphology | "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apptm1Somm/Apptm1Somm
Genetic Background: C57BL/6-Apptm1Somm
Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2+,Heg1tm1Mlkn/Heg1tm1Mlkn
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6
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| MP:0002792 | abnormal retinal vascularization | "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
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| MP:0002884 | abnormal branchial arches | "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Apptm1Somm/Apptm1Somm
Genetic Background: C57BL/6-Apptm1Somm
Allelic Composition: Ccm2tm1.1Kwhi/Ccm2tm1.1Kwhi
Genetic Background: involves: C57BL/6
Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1.1Kwhi,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0002925 | abnormal cardiovascular development | "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission] |
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL
|
| MP:0003227 | abnormal vascular branching morphogenesis | "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157] |
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Allelic Composition: Ccm2tm1Sbn/Ccm2tm1Sbn
Genetic Background: involves: C57BL/6
Allelic Composition: Ccm2tm2.1Sbn/Ccm2tm2.1Sbn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0003228 | abnormal sinus venosus | "malformation in the cavity at the caudal end of the embryonic cardiac tube in which the veins from the intra- and extraembryonic circulatory arcs unite; in the adult this becomes the portion of the right atrium known as the sinus of the vena cava" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157] |
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Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Ccm2tm1Etl Tg(Tek-cre)1Ywa
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| MP:0003229 | abnormal vitelline vasculature | "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257] |
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Allelic Composition: Apptm1Somm/Apptm1Somm
Genetic Background: C57BL/6-Apptm1Somm
Allelic Composition: Ccm2tm1.1Kwhi/Ccm2tm1.1Kwhi
Genetic Background: involves: C57BL/6
|
| MP:0003410 | abnormal artery development | "anomaly in the process of forming the blood vessels that carry blood away from the heart" [J:94740, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ccm2tm1Sbn/Ccm2tm1Sbn
Genetic Background: involves: C57BL/6
Allelic Composition: Ccm2tm2.1Sbn/Ccm2tm2.1Sbn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0003542 | abnormal vascular endothelial cell development | "malformation or aberrant differentiation of the cells that line the vasculature" [J:95387, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2+,Heg1tm1Mlkn/Heg1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0003719 | abnormal pericyte morphology | "malformation in the connective tissue cells that occurs around capillaries or other small blood vessels " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1Kwhi,Tg(Nes-cre)1Kln/?
Genetic Background: involves: C57BL/6 * SJL
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| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2+,Heg1tm1Mlkn/Heg1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Ccm2tm2.1Sbn/Ccm2tm2.1Sbn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0004068 | dilated dorsal aorta | "an expansion in the volume of the dorsal region of the main trunk of the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Apptm1Somm/Apptm1Somm
Genetic Background: C57BL/6-Apptm1Somm
Allelic Composition: Ccm2tm1.1Kwhi/Ccm2tm1.1Kwhi
Genetic Background: involves: C57BL/6
Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1.1Kwhi,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0004076 | abnormal vitelline vascular remodelling | "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Apptm1Somm/Apptm1Somm
Genetic Background: C57BL/6-Apptm1Somm
Allelic Composition: Ccm2tm1.1Kwhi/Ccm2tm1.1Kwhi
Genetic Background: involves: C57BL/6
Allelic Composition: Ccm2tm1Sbn/Ccm2tm1Sbn
Genetic Background: involves: C57BL/6
Allelic Composition: Ccm2tm2.1Sbn/Ccm2tm2.1Sbn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0004251 | failure of looping morphogenesis | "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ccm2tm1Sbn/Ccm2tm1Sbn
Genetic Background: involves: C57BL/6
Allelic Composition: Ccm2tm2.1Sbn/Ccm2tm2.1Sbn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0004266 | pale placenta | "placenta lacking normal reddish coloration, often refers to bloodless condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Ccm2tm1Etl Tg(Tek-cre)1Ywa
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| MP:0004783 | abnormal cardinal vein morphology | "any structural anomaly of any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Ccm2tm1Etl Tg(Tek-cre)1Ywa
Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2+,Heg1tm1Mlkn/Heg1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0004787 | abnormal dorsal aorta morphology | "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"] |
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Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Ccm2tm1Etl Tg(Tek-cre)1Ywa
Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2+,Heg1tm1Mlkn/Heg1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Ccm2tm2.1Sbn/Ccm2tm2.1Sbn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0004938 | dilated vasculature | "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ccm2tm1.1Etl/Ccm2tm1Etl,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: 129 * C57BL/6
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| MP:0004950 | abnormal brain vasculature | "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apptm1Somm/Apptm1Somm
Genetic Background: C57BL/6-Apptm1Somm
Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Ccm2tm1Etl Tg(Tek-cre)1Ywa
Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1.1Kwhi,Tg(Pdgfb-icre/ERT2)1Frut/?
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Ccm2tm2.1Sbn/Ccm2tm2.1Sbn,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Ccm2tm1.1Etl/Ccm2tm1Etl,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: 129 * C57BL/6
|
| MP:0005167 | abnormal blood-brain barrier | "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ccm2tm2.1Sbn/Ccm2tm2.1Sbn,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0005244 | hemopericardium | "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0] |
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2+,Heg1tm1Mlkn/Heg1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd
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| MP:0005592 | abnormal vascular smooth muscle morphology | "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ccm2tm1Sbn/Ccm2tm1Sbn
Genetic Background: involves: C57BL/6
Allelic Composition: Ccm2tm2.1Sbn/Ccm2tm2.1Sbn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0005602 | decreased angiogenesis | "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission] |
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Allelic Composition: Apptm1Somm/Apptm1Somm
Genetic Background: C57BL/6-Apptm1Somm
Allelic Composition: Ccm2tm1.1Kwhi/Ccm2tm1.1Kwhi
Genetic Background: involves: C57BL/6
Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1.1Kwhi,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0005621 | abnormal cell physiology | "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Npas3tm1Ewb/Npas3tm1Ewb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0006052 | cerebellum hemorrhage | "bleeding into the cerebellum" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ccm2tm2.1Sbn/Ccm2tm2.1Sbn,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Ccm2tm1.1Etl/Ccm2tm1Etl,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: 129 * C57BL/6
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| MP:0006055 | abnormal vascular endothelial cell morphology | "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ccm2tm1.1Etl/Ccm2tm1Etl,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl
Genetic Background: involves: 129
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| MP:0006082 | CNS inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request] |
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Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1Kwhi,Tg(Nes-cre)1Kln/?
Genetic Background: involves: C57BL/6 * SJL
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| MP:0006337 | abnormal first branchial arch morphology | "anomaly in the structure of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel s cartilage, trigeminal nerve, and maxillary artery" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ccm2tm1.1Kwhi/Ccm2tm1.1Kwhi
Genetic Background: involves: C57BL/6
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| MP:0006338 | abnormal second branchial arch morphology | "anomaly in the structure of the second arch which contributes to the development of the stapes, styloid process, hyoid bone, stylohyoid ligament, muscles of facial expression, stapedius muscle, stylohyoid muscle, and lining of the palatine tonsils" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ccm2tm1.1Kwhi/Ccm2tm1.1Kwhi
Genetic Background: involves: C57BL/6
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| MP:0006339 | abnormal third branchial arch morphology | "anomaly in the structure of the third are which contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ccm2tm1.1Kwhi/Ccm2tm1.1Kwhi
Genetic Background: involves: C57BL/6
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| MP:0006356 | abnormal third branchial arch artery morphology | "any structural anomaly of the vessels formed within the third pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apptm1Somm/Apptm1Somm
Genetic Background: C57BL/6-Apptm1Somm
Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1.1Kwhi,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0008725 | enlarged heart atrium | "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358] |
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Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Ccm2tm1Etl Tg(Tek-cre)1Ywa
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| MP:0008803 | abnormal placental labyrinth vasculature morphology | "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Ccm2tm1Etl Tg(Tek-cre)1Ywa
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| MP:0008918 | microgliosis | "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ccm2tm2.1Sbn/Ccm2tm2.1Sbn,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0009577 | abnormal developmental vascular remodeling | "any anomaly in the process by which existing vessels are reorganized during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ccm2tm1Sbn/Ccm2tm1Sbn
Genetic Background: involves: C57BL/6
Allelic Composition: Ccm2tm2.1Sbn/Ccm2tm2.1Sbn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0010355 | abnormal first branchial arch artery morphology | "any structural anomaly of the vessels formed within the first pair of branchial arches in embryogenesis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apptm1Somm/Apptm1Somm
Genetic Background: C57BL/6-Apptm1Somm
Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1.1Kwhi,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0010356 | abnormal second branchial arch artery morphology | "any structural anomaly of the vessels formed within the second pair of branchial arches in embryogenesis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apptm1Somm/Apptm1Somm
Genetic Background: C57BL/6-Apptm1Somm
Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1.1Kwhi,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0010463 | aorta stenosis | "diffuse constriction or narrowing of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apptm1Somm/Apptm1Somm
Genetic Background: C57BL/6-Apptm1Somm
Allelic Composition: Ccm2tm1.1Kwhi/Ccm2tm1.1Kwhi
Genetic Background: involves: C57BL/6
Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1.1Kwhi,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Ccm2tm1.1Etl/Ccm2tm1Etl,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: 129 * C57BL/6
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| MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Apptm1Somm/Apptm1Somm
Genetic Background: C57BL/6-Apptm1Somm
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Apptm1Somm/Apptm1Somm
Genetic Background: C57BL/6-Apptm1Somm
Allelic Composition: Ccm2tm1.1Etl/Ccm2tm1.1Etl
Genetic Background: B6.129-Ccm2tm1.1Etl
Allelic Composition: Ccm2tm1Etl/Ccm2tm1Etl,Tg(Tek-cre)1Ywa/0
Genetic Background: B6.Cg-Ccm2tm1Etl Tg(Tek-cre)1Ywa
Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2+,Heg1tm1Mlkn/Heg1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Ccm2tm1.1Kwhi/Ccm2tm1.1Kwhi
Genetic Background: involves: C57BL/6
Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1.1Kwhi,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Ccm2tm1Sbn/Ccm2tm1Sbn
Genetic Background: involves: C57BL/6
Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2+,Heg1tm1Mlkn/Heg1tm1Mlkn
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6
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| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0011514 | skin hemorrhage | "bleeding into the skin" [MGI:anna] |
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Allelic Composition: Ccm2tm1.1Etl/Ccm2tm1Etl,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: 129 * C57BL/6
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| MP:0012511 | dilated aortic sac | "abnormally stretched or widened aperture of the luminal space of the endothelial lined dilation that is located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates" [MGI:anna] |
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2+,Heg1tm1Mlkn/Heg1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd
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| MP:0030044 | short forehead | "an abnormally decreased height of the forehead" [MGI:anna] |
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Allelic Composition: Ccm2tm1Sbn/Ccm2tm1Sbn
Genetic Background: involves: C57BL/6
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