ENSMUSG00000000381


Mus musculus

Features
Gene ID: ENSMUSG00000000381
  
Biological name :Wap
  
Synonyms : Wap / whey acidic protein
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A1
Gene start: 6635482
Gene end: 6638637
  
Corresponding Affymetrix probe sets: 10384212 (MoGene1.0st)   1448386_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099974
NCBI entrez gene - 22373     See in Manteia.
MGI - MGI:98943
RefSeq - NM_011709
RefSeq - XM_017314502
RefSeq Peptide - NP_035839
swissprot - Q7M748
Ensembl - ENSMUSG00000000381
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008197  WAP-type "four-disulfide core" domain
 IPR036645  Elafin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Brca2tm1Brd/Brca2tm1Brd
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Brca2tm2Arge/Brca2tm2Arge,Waptm1(cre)Arge/Waptm1(cre)Arge
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Actbtm1(PyVT)Arge/Actb+,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bard1tm1Thl/Bard1tm2Thl,Waptm1(cre)Arge/0
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Bard1tm2Thl/Bard1tm2Thl,Waptm1(cre)Arge/0
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J

Allelic Composition: Brca1tm1Arge/Brca1tm1Thl,Waptm1(cre)Arge/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Allelic Composition: Brca1tm1Thl/Brca1tm1Thl,Waptm1(cre)Arge/0
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Bard1tm2Thl/Bard1tm2Thl,Brca1tm1Thl/Brca1tm1Thl,Waptm1(cre)Arge/0
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J

Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hgstm1Sug/Hgstm1Sug
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Igf1rtm2Arge/Igf1r+,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Igf1rtm2Arge/Igf1rtm2Arge,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Tg(tetO-HIST1H2BJ/GFP)47Efu/?,Waptm2(rtTA)Kuw/Wap+
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0004047 abnormal milk composition "anomaly in the protein or lipid content of milk" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk2tm1Ddg/Ntrk2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Actbtm1(PyVT)Arge/Actb+,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd,Trp53tm3Tyj/Trp53+,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Igf1rtm2Arge/Igf1r+,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Igf1rtm2Arge/Igf1rtm2Arge,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Thl,Trp53tm3Tyj/Trp53+,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd,Trp53tm3Tyj/Trp53+,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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