ENSMUSG00000000531


Mus musculus

Features
Gene ID: ENSMUSG00000000531
  
Biological name :Grasp
  
Synonyms : Grasp / Q9JJA9 / ral receptor for phosphoinositides 1-associated scaffold protein
  
Possible biological names infered from orthology : general receptor for phosphoinositides 1 associated scaffold protein / Q7Z6J2
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F1
Gene start: 101224188
Gene end: 101232756
  
Corresponding Affymetrix probe sets: 10427026 (MoGene1.0st)   1441894_s_at (Mouse Genome 430 2.0 Array)   1442616_at (Mouse Genome 430 2.0 Array)   1460206_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000543
NCBI entrez gene - 56149     See in Manteia.
MGI - MGI:1860303
RefSeq - NM_019518
RefSeq - XM_006521196
RefSeq Peptide - NP_062391
swissprot - Q9JJA9
Ensembl - ENSMUSG00000000531
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 graspENSDARG00000000588Danio rerio
 GRASPENSG00000161835Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cytip / Q91VY6 / Cytohesin-interacting protein / O60759* / cytohesin 1 interacting protein*ENSMUSG0000002683232


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport ISO
 biological_processGO:0007165 signal transduction IPI
 biological_processGO:0008104 protein localization IEA
 cellular_componentGO:0005641 nuclear envelope lumen ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0030306 ADP-ribosylation factor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Cd1d1tm1.1Aben/Cd1d1tm1.1Aben,Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic Background: C57BL/6-Cd1d1tm1.1Aben Tg(Itgax-cre,-EGFP)4097Ach

 MP:0001982 reduced chemically-elicited antinociception "less than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gabrg2tm1Wul/Gabrg2tm1Wul,Tg(Pcp2-cre)2Mpin/?,Tg(Pcp2-EGFP/Gabrg2)1Wul/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cd1d1tm1.1Aben/Cd1d1tm1.1Aben,Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic Background: C57BL/6-Cd1d1tm1.1Aben Tg(Itgax-cre,-EGFP)4097Ach

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabrg2tm1Wul/Gabrg2tm1Wul,Tg(Pcp2-cre)2Mpin/?,Tg(Pcp2-EGFP/Gabrg2)1Wul/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009757 impaired behavioral response to morphine "decreased sensitivity to morphine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabrg2tm1Wul/Gabrg2tm1Wul,Tg(Pcp2-cre)2Mpin/?,Tg(Pcp2-EGFP/Gabrg2)1Wul/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd1d1tm1.1Aben/Cd1d1tm1.1Aben,Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic Background: C57BL/6-Cd1d1tm1.1Aben Tg(Itgax-cre,-EGFP)4097Ach

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd1d1tm1.1Aben/Cd1d1tm1.1Aben,Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic Background: C57BL/6-Cd1d1tm1.1Aben Tg(Itgax-cre,-EGFP)4097Ach

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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