ENSMUSG00000000600


Mus musculus

Features
Gene ID: ENSMUSG00000000600
  
Biological name :Krit1
  
Synonyms : Krev interaction trapped protein 1 / Krit1 / Q6S5J6
  
Possible biological names infered from orthology : KRIT1, ankyrin repeat containing / O00522
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: A1
Gene start: 3803184
Gene end: 3845564
  
Corresponding Affymetrix probe sets: 10519392 (MoGene1.0st)   1428729_at (Mouse Genome 430 2.0 Array)   1428730_at (Mouse Genome 430 2.0 Array)   1439317_at (Mouse Genome 430 2.0 Array)   1442125_at (Mouse Genome 430 2.0 Array)   1448701_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132375
Ensembl peptide - ENSMUSP00000143776
Ensembl peptide - ENSMUSP00000143559
Ensembl peptide - ENSMUSP00000142657
Ensembl peptide - ENSMUSP00000078985
NCBI entrez gene - 79264     See in Manteia.
MGI - MGI:1930618
RefSeq - XM_006503618
RefSeq - NM_001170552
RefSeq - NM_030675
RefSeq - XM_006503617
RefSeq Peptide - NP_001164023
RefSeq Peptide - NP_109600
swissprot - B2RUA8
swissprot - A0A0G2JE71
swissprot - A0A0G2JGG7
swissprot - Q6S5J6
Ensembl - ENSMUSG00000000600
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 krit1ENSDARG00000098916Danio rerio
 KRIT1ENSGALG00000042651Gallus gallus
 KRIT1ENSG00000001631Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Frmd8 / Q3UFK8 / FERM domain-containing protein 8 / Q9BZ67* / FERM domain containing 8*ENSMUSG0000002481613


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR002110  Ankyrin repeat
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR020683  Ankyrin repeat-containing domain
 IPR032022  KRIT, N-terminal NPxY motif-rich region
 IPR035963  FERM superfamily, second domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation ISO
 biological_processGO:0010596 negative regulation of endothelial cell migration ISO
 biological_processGO:0016525 negative regulation of angiogenesis ISO
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0045454 cell redox homeostasis IMP
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:2000114 regulation of establishment of cell polarity IMP
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005911 cell-cell junction ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISS
 molecular_functionGO:0008017 microtubule binding ISO
 molecular_functionGO:0030695 GTPase regulator activity TAS
 molecular_functionGO:0044877 protein-containing complex binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Krit1tm1Kwhi/Krit1tm1.1Kwhi,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * SJL

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Comttm2(COMT)Xzho/Comttm2(COMT)Xzho
Genetic Background: involves: 129 * C57BL/6J

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krit1tm1Kwhi/Krit1tm1.1Kwhi,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * SJL

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Comttm2(COMT)Xzho/Comttm2(COMT)Xzho
Genetic Background: involves: 129 * C57BL/6J

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fzd4tm1.1(KOMP)Vlcg/Fzd4tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fzd4tm1.1(KOMP)Vlcg/Ucd

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002672 abnormal branchial arch artery morphology "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Comttm2(COMT)Xzho/Comttm2(COMT)Xzho
Genetic Background: involves: 129 * C57BL/6J

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccm2tm1.1Etl/Ccm2tm1Etl,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Krit1tm1Kwhi/Krit1tm1.1Kwhi,Tg(Pdgfb-icre/ERT2)1Frut/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * CBA

 MP:0002824 abnormal chorioallantoic fusion "abnormal process of or failure of the formation of the membrane that forms the fetal portion of the placenta; derived from the fusion of the chorion and the allantois" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0002861 abnormal tail bud morphology "anomalous formation of the primordial region of the embryo that arises to form the tail of the adult; appears approximately ten days following conception as a short stump, and then initiates elongation and thinning in normal development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Krit1tm1Kwhi/Krit1tm1.1Kwhi,Tg(Pdgfb-icre/ERT2)1Frut/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * CBA

 MP:0004175 telangiectases "vascular lesion formed by dilation of a group of small blood vessels" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Krit1tm1Kwhi/Krit1tm1.1Kwhi,Tg(Pdgfb-icre/ERT2)1Frut/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * CBA

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004938 dilated vasculature "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccm2tm1.1Etl/Ccm2tm1Etl,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Krit1tm1Kwhi/Krit1tm1.1Kwhi,Tg(Pdgfb-icre/ERT2)1Frut/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * CBA

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
Show

Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

 MP:0006182 retinal hemangioma "a benign tumor of the retina, originating from the overgrowth of blood vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Krit1tm1Kwhi/Krit1tm1.1Kwhi,Tg(Pdgfb-icre/ERT2)1Frut/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * CBA

 MP:0010574 aorta dilation "the luminal space of the aorta is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010662 abnormal intersomitic artery morphology "any structural anomaly of the small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Krit1tm1Sfre/Krit1tm1Sfre
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Krit1tm1Kwhi/Krit1tm1.1Kwhi,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * SJL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0012495 branchial arch artery stenosis "diffuse constriction or narrowing of the vessels formed within the six (five in mammals) pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [MGI:anna]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0013146 eye lesions "lesions on or around the eyes" [MGI:Ahmad_Retha]
Show

Allelic Composition: Krit1tm1Kwhi/Krit1tm1.1Kwhi,Tg(Pdgfb-icre/ERT2)1Frut/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * CBA

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr