ENSMUSG00000001150


Mus musculus

Features
Gene ID: ENSMUSG00000001150
  
Biological name :Mcm3ap
  
Synonyms : Mcm3ap / minichromosome maintenance complex component 3 associated protein / Q9WUU9
  
Possible biological names infered from orthology : O60318
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 76468927
Gene end: 76515857
  
Corresponding Affymetrix probe sets: 10364164 (MoGene1.0st)   1448711_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125960
Ensembl peptide - ENSMUSP00000151973
Ensembl peptide - ENSMUSP00000151327
NCBI entrez gene - 54387     See in Manteia.
MGI - MGI:1930089
RefSeq - NM_019434
RefSeq - XM_006513894
RefSeq Peptide - NP_062307
swissprot - A0A1W2P8E2
swissprot - Q9WUU9
swissprot - A0A1W2P6M1
Ensembl - ENSMUSG00000001150
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcm3apENSDARG00000021402Danio rerio
 MCM3APENSGALG00000004363Gallus gallus
 MCM3APENSG00000160294Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sac3d1 / SAC3 domain containing 1ENSMUSG000000247905


Protein motifs (from Interpro)
Interpro ID Name
 IPR005062  SAC3/GANP/THP3
 IPR031907  Germinal-centre associated nuclear protein, MCM3AP domain
 IPR031908  Germinal-centre associated nuclear protein, nucleoporin homology domain
 IPR031910  Germinal-centre associated nuclear protein, CID domain
 IPR034265  MCM3AP, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0051028 mRNA transport IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0003676 nucleic acid binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: CrygsOpj/CrygsOpj
Genetic Background: involves: 102 * C3H/He * T STOCK

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: CrygsOpj/CrygsOpj
Genetic Background: involves: 102 * C3H/He * T STOCK

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008093 abnormal memory B cell number "anomaly in the number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008192 abnormal germinal center B cell physiology "abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Igf2rtm1Rlj/Igf2r+,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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