ENSMUSG00000001418


Mus musculus

Features
Gene ID: ENSMUSG00000001418
  
Biological name :Glmp
  
Synonyms : Glmp / Glycosylated lysosomal membrane protein / Q9JHJ3
  
Possible biological names infered from orthology : Q8WWB7
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 88325023
Gene end: 88331313
  
Corresponding Affymetrix probe sets: 10493203 (MoGene1.0st)   1416830_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134809
Ensembl peptide - ENSMUSP00000135263
Ensembl peptide - ENSMUSP00000135398
Ensembl peptide - ENSMUSP00000135575
Ensembl peptide - ENSMUSP00000001454
Ensembl peptide - ENSMUSP00000120235
NCBI entrez gene - 56700     See in Manteia.
MGI - MGI:1913318
RefSeq - NM_020003
RefSeq Peptide - NP_064387
swissprot - Q9JHJ3
swissprot - D6RJI7
swissprot - H3BJ16
swissprot - H3BK59
swissprot - H3BKY1
swissprot - H9H9R4
Ensembl - ENSMUSG00000001418
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 glmpENSDARG00000059354Danio rerio
 GLMPENSGALG00000045611Gallus gallus
 GLMPENSG00000198715Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR029382  Lysosomal transcription factor, NCU-G1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)20Fwan/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/NCrl

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dpp9tm1.1Mdg/Dpp9+
Genetic Background: involves: C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Glmptm1Lex/Glmptm1Lex
Genetic Background: B6;129S5-Glmptm1Lex/Mmucd

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)20Fwan/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/NCrl

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Dpp9tm1.1Mdg/Dpp9+
Genetic Background: involves: C57BL/6

Allelic Composition: Glmptm1Lex/Glmptm1Lex
Genetic Background: B6;129S5-Glmptm1Lex/Mmucd

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dpp9tm1.1Mdg/Dpp9+
Genetic Background: involves: C57BL/6

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Glmptm1Lex/Glmptm1Lex
Genetic Background: B6;129S5-Glmptm1Lex/Mmucd

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Dpp9tm1.1Mdg/Dpp9+
Genetic Background: involves: C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dpp9tm1.1Mdg/Dpp9+
Genetic Background: involves: C57BL/6

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dpp9tm1.1Mdg/Dpp9+
Genetic Background: involves: C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dpp9tm1.1Mdg/Dpp9+
Genetic Background: involves: C57BL/6

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dpp9tm1.1Mdg/Dpp9+
Genetic Background: involves: C57BL/6

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Dpp9tm1.1Mdg/Dpp9+
Genetic Background: involves: C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Glmptm1Lex/Glmptm1Lex
Genetic Background: B6;129S5-Glmptm1Lex/Mmucd

 MP:0008114 abnormal Kupffer cell morphology "any structural anomaly of the phagocytic macrophages residing on the luminal surface of the hepatic sinusoids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dpp9tm1.1Mdg/Dpp9+
Genetic Background: involves: C57BL/6

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dpp9tm1.1Mdg/Dpp9+
Genetic Background: involves: C57BL/6

 MP:0008842 lipofuscinosis "storage in organs of brownish fatty pigment resulting from the breakdown and absorption of damaged blood cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dpp9tm1.1Mdg/Dpp9+
Genetic Background: involves: C57BL/6

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dpp9tm1.1Mdg/Dpp9+
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr