Manteia - Molecule gene

ENSMUSG00000001420

Mus musculus

Features

Gene ID:	ENSMUSG00000001420

Biological name :	Tmem79

Synonyms :	Q9D709 / Tmem79 / Transmembrane protein 79

Possible biological names infered from orthology :	Q9BSE2

Species:	Mus musculus

Chr. number:	3
Strand:	-1
Band:	F1
Gene start:	88328655
Gene end:	88336148

Corresponding Affymetrix probe sets:	10499348 (MoGene1.0st) 1430483_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000141830 Ensembl peptide - ENSMUSP00000001456 Ensembl peptide - ENSMUSP00000103176 Ensembl peptide - ENSMUSP00000103177 NCBI entrez gene - 71913 See in Manteia. MGI - MGI:1919163 RefSeq - NM_024246 RefSeq - XM_006502124 RefSeq - XM_006502125 RefSeq Peptide - NP_077208 swissprot - A0A0A6YX45 swissprot - Q9D709 Ensembl - ENSMUSG00000001420

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
tmem79a	ENSDARG00000071250	Danio rerio
tmem79b	ENSDARG00000076861	Danio rerio
TMEM79	ENSGALG00000039643	Gallus gallus
Q9BSE2	ENSG00000163472	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR023352	Membrane associated eicosanoid/glutathione metabolism-like domain superfamily
IPR033582	Transmembrane protein 79

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002070	epithelial cell maturation	IMP
biological_process	GO:0031069	hair follicle morphogenesis	IMP
biological_process	GO:0042335	cuticle development	IMP
biological_process	GO:0045055	regulated exocytosis	IMP
biological_process	GO:0045684	positive regulation of epidermis development	IMP
biological_process	GO:0061436	establishment of skin barrier	IEA
biological_process	GO:0070268	cornification	IEA
cellular_component	GO:0005737	cytoplasm	IDA
cellular_component	GO:0005764	lysosome	IEA
cellular_component	GO:0005765	lysosomal membrane	IDA
cellular_component	GO:0005794	Golgi apparatus	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0032588	trans-Golgi network membrane	IEA
molecular_function	GO:0042802	identical protein binding	ISO

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000367	abnormal coat/ hair morphology	"anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dido1^tm1Cmar/Dido1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000402	abnormal zigzag hairs	"anomalies of truncal hairs that contain one air cell in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cntnap1^shm-4J/Cntnap1^shm-4J Genetic Background: involves: C3H/HeDiSn * Swiss stock
MP:0000403	increased curvature of zigzag hairs	"greater bending arch of the zigzag hairs" [J:47620]	Show Allelic Composition: Cntnap1^shm-4J/Cntnap1^shm-4J Genetic Background: involves: C3H/HeDiSn * Swiss stock
MP:0000411	shiny fur	"fur with a glossy or glistening appearance" [J:45065]	Show Allelic Composition: Cntnap1^shm-4J/Cntnap1^shm-4J Genetic Background: involves: C3H/HeDiSn * Swiss stock
MP:0000414	alopecia	"absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]	Show Allelic Composition: Il6^tm1Mur/Il6^tm1Mur Genetic Background: B6.129P2(B6)-Il6^tm1Mur Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: C57BL/6J * CBA/CaGr Allelic Composition: Tmem79^ma/Tmem79^ma Genetic Background: involves: C57BL/Gr * CBA/CaGr Allelic Composition: Tmem79^ma/Tmem79^ma Genetic Background: B6.CBACaGr-Tmem79^ma/J Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: CBA/CaGr
MP:0000416	sparse fur	"fur that is significantly less dense" [J:46854]	Show Allelic Composition: Cntnap1^shm-4J/Cntnap1^shm-4J Genetic Background: involves: C3H/HeDiSn * Swiss stock
MP:0000427	abnormal hair cycle	"aberrant growth or asynchronous timing of the hair growth " [J:65302]	Show Allelic Composition: Il6^tm1Mur/Il6^tm1Mur Genetic Background: B6.129P2(B6)-Il6^tm1Mur
MP:0001191	abnormal skin condition	"anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cntnap1^shm-4J/Cntnap1^shm-4J Genetic Background: involves: C3H/HeDiSn * Swiss stock
MP:0001192	scaly skin	"skin covered with shedding scales or flakes" [J:65146]	Show Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: CBA/CaGr
MP:0001194	dermatitis	"inflammation of the skin" [J:65146]	Show Allelic Composition: Bak1^tm1Thsn/Bak1^tm1Thsn,Bax^tm1Sjk/Bax^tm2Sjk,Kras^tm4Tyj/Kras⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 Allelic Composition: Tmem79^ma/Tmem79^ma Genetic Background: B6.CBACaGr-Tmem79^ma/J
MP:0001240	abnormal cornified layer morphology	"structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Bak1^tm1Thsn/Bak1^tm1Thsn,Bax^tm1Sjk/Bax^tm2Sjk,Kras^tm4Tyj/Kras⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0001412	excessive scratching	"compulsive scraping of the skin, usually with the nails" [J:61340]	Show Allelic Composition: Bak1^tm1Thsn/Bak1^tm1Thsn,Bax^tm1Sjk/Bax^tm2Sjk,Kras^tm4Tyj/Kras⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0001489	decreased startle reflex	"greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]	Show Allelic Composition: Tmem115^{tm1.1(KOMP)Vlcg}/Tmem115⁺ Genetic Background: C57BL/6N-Tmem115^{tm1.1(KOMP)Vlcg}/Ucd
MP:0001510	abnormal coat appearance	"coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Il6^tm1Mur/Il6^tm1Mur Genetic Background: B6.129P2(B6)-Il6^tm1Mur Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: C57BL/6J * CBA/CaGr Allelic Composition: Tmem79^ma/Tmem79^ma Genetic Background: involves: C57BL/Gr * CBA/CaGr Allelic Composition: Tmem79^ma/Tmem79^ma Genetic Background: B6.CBACaGr-Tmem79^ma/J Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: CBA/CaGr Allelic Composition: Tmem79^{tm1.1(KOMP)Wtsi}/Tmem79^{tm1.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Tmem79^{tm1.1(KOMP)Wtsi}/J
MP:0001874	acanthosis	"diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bak1^tm1Thsn/Bak1^tm1Thsn,Bax^tm1Sjk/Bax^tm2Sjk,Kras^tm4Tyj/Kras⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 Allelic Composition: Tmem79^ma/Tmem79^ma Genetic Background: B6.CBACaGr-Tmem79^ma/J Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: CBA/CaGr
MP:0002073	abnormal hair growth	"absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: C57BL/6J * CBA/CaGr
MP:0002075	abnormal coat color	"irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cntnap1^shm-4J/Cntnap1^shm-4J Genetic Background: involves: C3H/HeDiSn * Swiss stock
MP:0002497	increased IgE	"greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tmem79^ma/Tmem79^ma Genetic Background: B6.CBACaGr-Tmem79^ma/J Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: CBA/CaGr
MP:0002796	impaired skin barrier function	"impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]	Show Allelic Composition: Bak1^tm1Thsn/Bak1^tm1Thsn,Bax^tm1Sjk/Bax^tm2Sjk,Kras^tm4Tyj/Kras⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 Allelic Composition: Tmem79^ma/Tmem79^ma Genetic Background: B6.CBACaGr-Tmem79^ma/J Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: CBA/CaGr
MP:0003704	abnormal hair follicle development	"anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Tmem79^ma/Tmem79^ma Genetic Background: B6.CBACaGr-Tmem79^ma/J
MP:0003809	abnormal hair shaft morphology	"irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Il6^tm1Mur/Il6^tm1Mur Genetic Background: B6.129P2(B6)-Il6^tm1Mur Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: C57BL/6J * CBA/CaGr
MP:0003810	abnormal hair cuticle	"anomalies in the thin, smooth and glossy outer protective cell layer of hair shaft" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Il6^tm1Mur/Il6^tm1Mur Genetic Background: B6.129P2(B6)-Il6^tm1Mur Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: CBA/CaGr
MP:0003846	matted coat	"coat hairs sticks together to form clumps and does not lie flat" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Il6^tm1Mur/Il6^tm1Mur Genetic Background: B6.129P2(B6)-Il6^tm1Mur Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: C57BL/6J * CBA/CaGr Allelic Composition: Tmem79^ma/Tmem79^ma Genetic Background: involves: C57BL/Gr * CBA/CaGr Allelic Composition: Tmem79^ma/Tmem79^ma Genetic Background: involves: C57BL/6JJcl * CBA/CaGr Allelic Composition: Tmem79^ma/Tmem79^ma Genetic Background: B6.CBACaGr-Tmem79^ma/J Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: CBA/CaGr
MP:0003848	brittle hair	"hair is susceptible to breakage " [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Tmem79^ma/Tmem79^ma Genetic Background: B6.CBACaGr-Tmem79^ma/J Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: CBA/CaGr
MP:0003853	dry skin	"skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: CBA/CaGr
MP:0003960	increased lean body mass	"more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Tmem79^{tm1.1(KOMP)Wtsi}/Tmem79^{tm1.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Tmem79^{tm1.1(KOMP)Wtsi}/J
MP:0004947	skin inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tmem79^ma/Tmem79^ma Genetic Background: B6.CBACaGr-Tmem79^ma/J Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: CBA/CaGr
MP:0005103	abnormal retinal pigmentation	"anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tmem79^{tm1.1(KOMP)Wtsi}/Tmem79^{tm1.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Tmem79^{tm1.1(KOMP)Wtsi}/J
MP:0005251	blepharitis	"inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tmem79^ma/Tmem79^ma Genetic Background: B6.CBACaGr-Tmem79^ma/J Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: CBA/CaGr
MP:0005409	darkened coat color	"amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreasesd when compared to wild-type agouti" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Tmem79^ma/Tmem79^ma Genetic Background: involves: C57BL/Gr * CBA/CaGr
MP:0009594	abnormal corneocyte envelope morphology	"any structural or developmental anomaly of the electron-dense layer of highly transglutaminase cross-linked protein that is deposited on the inner surface of the plasma membrane of corneocytes in the outermost layers of the epidermis; a monomolecular layer of ceramides is covalently attached to the outer surface of the CE to form a hydrophobic lipid envelope that covers each corneocyte and provides continuity with the lipid matrix" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tmem79^ma/Tmem79^ma Genetic Background: B6.CBACaGr-Tmem79^ma/J
MP:0009675	orthokeratosis	"thickening of the stratum corneum of the epidermis (hyperkeratosis) with non-nucleated keratinocytes retained in this layer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tmem79^ma/Tmem79^ma Genetic Background: B6.CBACaGr-Tmem79^ma/J Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: CBA/CaGr
MP:0009801	abnormal hair cortex keratinization	"any defect in the formation of the fibrous elements found in the hair cortex comprising acidic (Type I ) and basic (Type II) proteins that give hair such aspects as resilience, and elasticity" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tmem79^ma/Tmem79^ma Genetic Background: B6.CBACaGr-Tmem79^ma/J Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: CBA/CaGr
MP:0009931	abnormal skin appearance	"skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: CBA/CaGr
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tmem79^{tm1.1(KOMP)Wtsi}/Tmem79^{tm1.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Tmem79^{tm1.1(KOMP)Wtsi}/J
MP:0010686	abnormal hair follicle matrix region morphology	"any structural anomaly of the bulb region adjacent to the dermal papilla that contains rapidly proliferating matrix cells that give rise to the various cell lineages of the hair shaft and inner root sheath" [PMID:19211055]	Show Allelic Composition: Flg^ft/Flg^ft,Tmem79^ma/Tmem79^ma Genetic Background: involves: C57BL/6J * CBA/CaGr
MP:0011275	abnormal behavioral response to light	"unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]	Show Allelic Composition: Tmem79^{tm1.1(KOMP)Wtsi}/Tmem79^{tm1.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Tmem79^{tm1.1(KOMP)Wtsi}/J
MP:0011396	abnormal sleep behavior	"any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]	Show Allelic Composition: Tmem79^{tm1.1(KOMP)Wtsi}/Tmem79^{tm1.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Tmem79^{tm1.1(KOMP)Wtsi}/J
MP:0013278	decreased fasted circulating glucose level	"reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]	Show Allelic Composition: Tmem79^{tm1.1(KOMP)Wtsi}/Tmem79^{tm1.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Tmem79^{tm1.1(KOMP)Wtsi}/J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr