ENSMUSG00000001518


Mus musculus

Features
Gene ID: ENSMUSG00000001518
  
Biological name :Itfg2
  
Synonyms : Itfg2 / KICSTOR complex protein ITFG2 / Q91WI7
  
Possible biological names infered from orthology : integrin alpha FG-GAP repeat containing 2 / Q969R8
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F3
Gene start: 128409444
Gene end: 128424931
  
Corresponding Affymetrix probe sets: 10548180 (MoGene1.0st)   1418032_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144837
Ensembl peptide - ENSMUSP00000145388
Ensembl peptide - ENSMUSP00000145323
Ensembl peptide - ENSMUSP00000145282
Ensembl peptide - ENSMUSP00000145111
Ensembl peptide - ENSMUSP00000001559
NCBI entrez gene - 101142     See in Manteia.
MGI - MGI:1915450
RefSeq - XM_006505230
RefSeq - NM_133927
RefSeq - XM_006505229
RefSeq Peptide - NP_598688
swissprot - A0A0N4SW62
swissprot - A0A0N4SW06
swissprot - Q91WI7
swissprot - A0A0N4SVX2
swissprot - A0A0N4SUV5
swissprot - Q3TWL5
Ensembl - ENSMUSG00000001518
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itfg2ENSDARG00000002174Danio rerio
 ITFG2ENSGALG00000014335Gallus gallus
 ITFG2ENSG00000111203Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR031793  Integrin-alpha FG-GAP repeat-containing protein 2
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002314 germinal center B cell differentiation IMP
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0042149 cellular response to glucose starvation IEA
 biological_processGO:1904262 negative regulation of TORC1 signaling IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane ISO
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0140007 KICSTOR complex IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Faslpr/Faslpr,Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Clec1btm2Mlkn/Clec1btm2Mlkn,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Faslpr/Faslpr,Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Clec1btm2Mlkn/Clec1btm2Mlkn,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clec1btm2Mlkn/Clec1btm2Mlkn,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Faslpr/Faslpr,Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Faslpr/Faslpr,Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clec1btm2Mlkn/Clec1btm2Mlkn,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clec1btm2Mlkn/Clec1btm2Mlkn,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clec1btm2Mlkn/Clec1btm2Mlkn,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Faslpr/Faslpr,Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Faslpr/Faslpr,Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clec1btm2Mlkn/Clec1btm2Mlkn,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Clec1btm2Mlkn/Clec1btm2Mlkn,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clec1btm2Mlkn/Clec1btm2Mlkn,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clec1btm2Mlkn/Clec1btm2Mlkn,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clec1btm2Mlkn/Clec1btm2Mlkn,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clec1btm2Mlkn/Clec1btm2Mlkn,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

 MP:0009333 abnormal splenocyte physiology "any functional anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clec1btm2Mlkn/Clec1btm2Mlkn,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0010187 decreased T follicular helper cell number "reduced number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
Show

Allelic Composition: Clec1btm2Mlkn/Clec1btm2Mlkn,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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