ENSMUSG00000001707


Mus musculus

Features
Gene ID: ENSMUSG00000001707
  
Biological name :Eef1e1
  
Synonyms : Eef1e1 / Eukaryotic translation elongation factor 1 epsilon-1 / Q9D1M4
  
Possible biological names infered from orthology : EEF1E1-BLOC1S5 / EEF1E1-BLOC1S5 readthrough (NMD candidate) / O43324
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.3
Gene start: 38644207
Gene end: 38659058
  
Corresponding Affymetrix probe sets: 10408762 (MoGene1.0st)   1444757_at (Mouse Genome 430 2.0 Array)   1449044_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001757
NCBI entrez gene - 66143     See in Manteia.
MGI - MGI:1913393
RefSeq - NM_025380
RefSeq Peptide - NP_079656
swissprot - Q9D1M4
Ensembl - ENSMUSG00000001707
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eef1e1ENSDARG00000071774Danio rerio
 ENSGALG00000012781Gallus gallus
 EEF1E1ENSG00000124802Homo sapiens
 EEF1E1-BLOC1S5ENSG00000265818Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004046  Glutathione S-transferase, C-terminal
 IPR010987  Glutathione S-transferase, C-terminal-like
 IPR036282  Glutathione S-transferase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006749 glutathione metabolic process IBA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator IMP
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 biological_processGO:2000774 positive regulation of cellular senescence ISO
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0017101 aminoacyl-tRNA synthetase multienzyme complex NAS
 molecular_functionGO:0004364 glutathione transferase activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Birc6tm1Nai/Birc6tm1Nai
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002018 malignant tumors "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]
Show

Allelic Composition: Birc6tm1Nai/Birc6tm1Nai
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Birc6tm1Nai/Birc6tm1Nai
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009336 increased splenocyte proliferation "increase in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Birc6tm1Nai/Birc6tm1Nai
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009341 decreased splenocyte apoptosis "reduction in the number of spleen cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Birc6tm1Nai/Birc6tm1Nai
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Birc6tm1Nai/Birc6tm1Nai
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011107 partial embryonic lethality before turning of embryo "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Birc6tm1Nai/Birc6tm1Nai
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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