ENSMUSG00000001774


Mus musculus

Features
Gene ID: ENSMUSG00000001774
  
Biological name :Chordc1
  
Synonyms : Chordc1 / Cysteine and histidine-rich domain-containing protein 1 / Q9D1P4
  
Possible biological names infered from orthology : cysteine and histidine rich domain containing 1 / Q9UHD1
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A2
Gene start: 18292125
Gene end: 18317442
  
Corresponding Affymetrix probe sets: 10583347 (MoGene1.0st)   1435574_at (Mouse Genome 430 2.0 Array)   1460645_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001825
Ensembl peptide - ENSMUSP00000150569
Ensembl peptide - ENSMUSP00000150527
Ensembl peptide - ENSMUSP00000150443
Ensembl peptide - ENSMUSP00000149900
NCBI entrez gene - 66917     See in Manteia.
MGI - MGI:1914167
RefSeq - NM_025844
RefSeq Peptide - NP_080120
swissprot - A0A1L1SSG7
swissprot - A0A1L1SU22
swissprot - Q9D1P4
swissprot - A0A1L1STZ1
swissprot - A0A1L1STQ1
Ensembl - ENSMUSG00000001774
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chordc1aENSDARG00000003973Danio rerio
 chordc1bENSDARG00000017067Danio rerio
 CHORDC1ENSGALG00000035461Gallus gallus
 Q9UHD1ENSG00000110172Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9R000 / Itgb1bp2 / Integrin beta-1-binding protein 2 / Q9UKP3* / integrin subunit beta 1 binding protein 2*ENSMUSG0000003131248


Protein motifs (from Interpro)
Interpro ID Name
 IPR007051  CHORD domain
 IPR007052  CS domain
 IPR008978  HSP20-like chaperone


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010824 regulation of centrosome duplication IMP
 biological_processGO:0061077 chaperone-mediated protein folding IDA
 biological_processGO:1900034 regulation of cellular response to heat IDA
 biological_processGO:2000299 negative regulation of Rho-dependent protein serine/threonine kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0043531 ADP binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051879 Hsp90 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atxn10Gt(OST237477)Lex/Atxn10Gt(OST237477)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Atxn10Gt(OST237477)Lex/Atxn10Gt(OST237477)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Atxn10Gt(OST237477)Lex/Atxn10Gt(OST237477)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atxn10Gt(OST237477)Lex/Atxn10Gt(OST237477)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Atxn10Gt(OST237477)Lex/Atxn10Gt(OST237477)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Atxn10Gt(OST237477)Lex/Atxn10Gt(OST237477)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Atxn10Gt(OST237477)Lex/Atxn10Gt(OST237477)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Atxn10Gt(OST237477)Lex/Atxn10Gt(OST237477)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atxn10Gt(OST237477)Lex/Atxn10Gt(OST237477)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atxn10Gt(OST237477)Lex/Atxn10Gt(OST237477)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Atxn10Gt(OST237477)Lex/Atxn10Gt(OST237477)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Atxn10Gt(OST237477)Lex/Atxn10Gt(OST237477)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atxn10Gt(OST237477)Lex/Atxn10Gt(OST237477)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Atxn10Gt(OST237477)Lex/Atxn10Gt(OST237477)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005481 chronic myelocytic leukemia "a heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atxn10Gt(OST237477)Lex/Atxn10Gt(OST237477)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atxn10Gt(OST237477)Lex/Atxn10Gt(OST237477)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0010039 abnormal trophoblast giant cell proliferation "abnormality in the expansion rate of the trophoblast giant cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

 MP:0010380 inner cell mass apoptosis "the cells of the blastocyst that develop into the body of the embryo are undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

 MP:0013415 increased myeloid cell number in bone marrow "increase in the number of CD45+ CD11b+ GR1- myeloid cells in the bone marrow" [IMPC:Saran]
Show

Allelic Composition: Atxn10Gt(OST237477)Lex/Atxn10Gt(OST237477)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0013663 increased myeloid cell number "greater than the expected number of cells of the myeloid lineage" [CL:0000763]
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Allelic Composition: Atxn10Gt(OST237477)Lex/Atxn10Gt(OST237477)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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