ENSMUSG00000001785


Mus musculus

Features
Gene ID: ENSMUSG00000001785
  
Biological name :Pwp1
  
Synonyms : Periodic tryptophan / Pwp1 / Q99LL5
  
Possible biological names infered from orthology : PWP1 homolog, endonuclein / Q13610
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 85829494
Gene end: 85889096
  
Corresponding Affymetrix probe sets: 10365450 (MoGene1.0st)   1417873_at (Mouse Genome 430 2.0 Array)   1454142_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001836
Ensembl peptide - ENSMUSP00000152025
Ensembl peptide - ENSMUSP00000151813
NCBI entrez gene - 103136     See in Manteia.
MGI - MGI:1914735
RefSeq - NM_133993
RefSeq Peptide - NP_598754
swissprot - A0A1W2P8G3
swissprot - A0A1W2P7U7
swissprot - Q99LL5
Ensembl - ENSMUSG00000001785
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pwp1ENSDARG00000015921Danio rerio
 PWP1ENSGALG00000012631Gallus gallus
 PWP1ENSG00000136045Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein IMP
 biological_processGO:0034773 histone H4-K20 trimethylation IMP
 biological_processGO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IEA
 biological_processGO:2000738 positive regulation of stem cell differentiation IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:1990889 H4K20me3 modified histone binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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