ENSMUSG00000001942


Mus musculus

Features
Gene ID: ENSMUSG00000001942
  
Biological name :Siae
  
Synonyms : P70665 / Siae / Sialate O-acetylesterase Sialate O-acetylesterase small subunit Sialate O-acetylesterase large subunit
  
Possible biological names infered from orthology : Q9HAT2 / sialic acid acetylesterase
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A4
Gene start: 37555698
Gene end: 37649655
  
Corresponding Affymetrix probe sets: 10584334 (MoGene1.0st)   1416538_at (Mouse Genome 430 2.0 Array)   1416539_at (Mouse Genome 430 2.0 Array)   1459058_at (Mouse Genome 430 2.0 Array)   1460387_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002007
Ensembl peptide - ENSMUSP00000150641
Ensembl peptide - ENSMUSP00000149505
Ensembl peptide - ENSMUSP00000149220
Ensembl peptide - ENSMUSP00000149029
NCBI entrez gene - 22619     See in Manteia.
MGI - MGI:104803
RefSeq - NM_011734
RefSeq Peptide - NP_035864
swissprot - A0A1L1SQF7
swissprot - A0A1N9M4K1
swissprot - P70665
swissprot - A0A1L1SU77
swissprot - A0A1L1SQX0
Ensembl - ENSMUSG00000001942
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 siaeENSDARG00000040527Danio rerio
 SIAEENSG00000110013Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005181  Sialate O-acetylesterase domain
 IPR036514  SGNH hydrolase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002682 regulation of immune system process IEA
 biological_processGO:0005975 carbohydrate metabolic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 molecular_functionGO:0001681 sialate O-acetylesterase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rims1tm3.1Sud/Rims1tm3.1Sud
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0004796 increased anti-histone antibody level "elevated level of antibodies to histones present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0008169 increased B-1b cell number "greater number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd Cmahtm1Avrk

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd Cmahtm1Avrk

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd Cmahtm1Avrk

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0010835 increased CD4-positive, alpha-beta memory T cell number "increased number of CD4-positive, alpha-beta long-lived T cells with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000897, GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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