ENSMUSG00000001999


Mus musculus

Features
Gene ID: ENSMUSG00000001999
  
Biological name :Blvra
  
Synonyms : Biliverdin reductase A / Blvra / Q9CY64
  
Possible biological names infered from orthology : P53004
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 127070665
Gene end: 127097084
  
Corresponding Affymetrix probe sets: 10475708 (MoGene1.0st)   1428580_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106019
Ensembl peptide - ENSMUSP00000118278
Ensembl peptide - ENSMUSP00000116825
Ensembl peptide - ENSMUSP00000002064
NCBI entrez gene - 109778     See in Manteia.
MGI - MGI:88170
RefSeq - XM_006498569
RefSeq - XM_006498571
RefSeq - XM_006498572
RefSeq - XM_006498573
RefSeq - NM_026678
RefSeq Peptide - NP_080954
swissprot - Q9CY64
swissprot - A2ASB7
swissprot - A2ASB1
swissprot - A2ASB8
Ensembl - ENSMUSG00000001999
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 blvraENSDARG00000059857Danio rerio
 BLVRAENSGALG00000031786Gallus gallus
 BLVRAENSG00000106605Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000683  Oxidoreductase, N-terminal
 IPR015249  Biliverdin reductase, catalytic
 IPR017094  Biliverdin reductase A
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0042167 heme catabolic process ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding ISO
 molecular_functionGO:0004074 biliverdin reductase activity ISO
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Heme degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0010398 decreased liver glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0014174 decreased fatty acid beta-oxidation "decreased rate or incidence of the process that results in the complete oxidation of a long-chain fatty acid, beginning with the addition of coenzyme A to a fatty acid, with successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)" [GO:0006635]
Show

Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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