ENSMUSG00000002058


Mus musculus

Features
Gene ID: ENSMUSG00000002058
  
Biological name :Unc119
  
Synonyms : Q9Z2R6 / Unc119 / unc-119 lipid binding chaperone
  
Possible biological names infered from orthology : Q13432
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 78343482
Gene end: 78349164
  
Corresponding Affymetrix probe sets: 10379176 (MoGene1.0st)   1418123_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103930
Ensembl peptide - ENSMUSP00000002127
Ensembl peptide - ENSMUSP00000098318
NCBI entrez gene - 22248     See in Manteia.
MGI - MGI:1328357
RefSeq - NM_001313987
RefSeq - NM_001313985
RefSeq - NM_001313986
RefSeq - NM_001313988
RefSeq - NM_011676
RefSeq Peptide - NP_001300914
RefSeq Peptide - NP_001300917
RefSeq Peptide - NP_035806
RefSeq Peptide - NP_001300915
RefSeq Peptide - NP_001300916
swissprot - B1AQD7
swissprot - Q9Z2R6
swissprot - B1AQD9
swissprot - Q3V299
Ensembl - ENSMUSG00000002058
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 unc119aENSDARG00000034453Danio rerio
 unc119bENSDARG00000044362Danio rerio
 UNC119ENSGALG00000003657Gallus gallus
 Q13432ENSG00000109103Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8C4B4 / Unc119b / unc-119 lipid binding chaperone B / A6NIH7*ENSMUSG0000004656251


Protein motifs (from Interpro)
Interpro ID Name
 IPR008015  GMP phosphodiesterase, delta subunit
 IPR014756  Immunoglobulin E-set
 IPR032977  Protein unc-119 homologue A-like
 IPR037036  GMP phosphodiesterase, delta subunit superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0042953 lipoprotein transport IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:1900186 negative regulation of clathrin-dependent endocytosis IMP
 biological_processGO:2001287 negative regulation of caveolin-mediated endocytosis IMP
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0045171 intercellular bridge IEA
 cellular_componentGO:0051233 spindle midzone IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Sufutm1b(KOMP)Wtsi/Sufutm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Sufutm1b(KOMP)Wtsi/Ucd

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2tm1.1Eno,Tg(Myh6-cre)2182Mds/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2tm1.1Eno,Tg(Myh6-cre)2182Mds/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Sufutm1b(KOMP)Wtsi/Sufutm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Sufutm1b(KOMP)Wtsi/Ucd

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2tm1.1Eno,Tg(Myh6-cre)2182Mds/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2tm1.1Eno,Tg(Myh6-cre)2182Mds/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2tm1.1Eno,Tg(Myh6-cre)2182Mds/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N

Allelic Composition: Unc119tm1Gina/Unc119tm1Gina
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
Show

Allelic Composition: Unc119tm1Gina/Unc119tm1Gina
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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