ENSMUSG00000002083


Mus musculus

Features
Gene ID: ENSMUSG00000002083
  
Biological name :Bbc3
  
Synonyms : Bbc3 / Bcl-2-binding component 3 / Q99ML1
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A2
Gene start: 16308393
Gene end: 16318205
  
Corresponding Affymetrix probe sets: 10550290 (MoGene1.0st)   1423315_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119225
Ensembl peptide - ENSMUSP00000147422
Ensembl peptide - ENSMUSP00000002152
NCBI entrez gene - 170770     See in Manteia.
MGI - MGI:2181667
RefSeq - XM_006539582
RefSeq - XM_006539577
RefSeq - XM_006539578
RefSeq - XM_006539579
RefSeq - XM_006539580
RefSeq - XM_006539581
RefSeq - NM_133234
RefSeq - XM_006539575
RefSeq Peptide - NP_573497
swissprot - D3Z2M5
swissprot - B2RVL4
swissprot - A0A1B0GR88
swissprot - Q99ML1
Ensembl - ENSMUSG00000002083
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR031661  Bcl-2-binding component 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001836 release of cytochrome c from mitochondria ISS
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0006974 cellular response to DNA damage stimulus IGI
 biological_processGO:0008340 determination of adult lifespan IGI
 biological_processGO:0030308 negative regulation of cell growth ISO
 biological_processGO:0032464 positive regulation of protein homooligomerization ISO
 biological_processGO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration ISO
 biological_processGO:0034976 response to endoplasmic reticulum stress ISO
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IMP
 biological_processGO:0045926 negative regulation of growth ISS
 biological_processGO:0051209 release of sequestered calcium ion into cytosol ISO
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
 biological_processGO:0070245 positive regulation of thymocyte apoptotic process IGI
 biological_processGO:0071479 cellular response to ionizing radiation IGI
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator ISO
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:0097190 apoptotic signaling pathway ISO
 biological_processGO:0097193 intrinsic apoptotic signaling pathway IEA
 biological_processGO:0097194 execution phase of apoptosis ISS
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway ISO
 biological_processGO:1901998 toxin transport IMP
 biological_processGO:2001056 positive regulation of cysteine-type endopeptidase activity IMP
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005740 mitochondrial envelope ISO
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051117 ATPase binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bbc3tm1Ast/Bbc3tm1Ast
Genetic Background: C57BL/6-Bbc3tm1Ast

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ercc1tm1Dwm/Ercc1tm2Dwm,Hrhr/Hrhr,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J * MF1

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Bbc3tm1Gpz/Bbc3tm1Gpz,Trp53tm1Brd/Trp53tm8Xu
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-v/KitW-v,Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: KitW-v/KitW-v,Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-v/KitW-v,Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-v/KitW-v,Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bbc3tm1Gpz/Bbc3tm1Gpz,Bnip3ltm1Ney/Bnip3ltm1Ney
Genetic Background: involves: 129P2/OlaHsd

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ercc1tm1Dwm/Ercc1tm2Dwm,Hrhr/Hrhr,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J * MF1

 MP:0003207 decreased sensitivity to gamma-irradiation "decreased incidence of cell death following high levels of gamma-irradiation" [J:92917, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ercc1tm1Dwm/Ercc1tm2Dwm,Hrhr/Hrhr,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J * MF1

Allelic Composition: Bbc3tm1Ast/Bbc3tm1Ast
Genetic Background: C57BL/6-Bbc3tm1Ast

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Ercc1tm1Dwm/Ercc1tm2Dwm,Hrhr/Hrhr,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J * MF1

 MP:0003823 increased left ventricular developed pressure "increase in the difference between left ventricular systolic and diastolic pressures" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ercc1tm1Dwm/Ercc1tm2Dwm,Hrhr/Hrhr,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J * MF1

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bbc3tm1Ast/Bbc3tm1Ast
Genetic Background: C57BL/6-Bbc3tm1Ast

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Bbc3tm1Ast/Bbc3tm1Ast
Genetic Background: C57BL/6-Bbc3tm1Ast

 MP:0005571 decreased lactate dehydrogenase level "less than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ercc1tm1Dwm/Ercc1tm2Dwm,Hrhr/Hrhr,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J * MF1

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ercc1tm1Dwm/Ercc1tm2Dwm,Hrhr/Hrhr,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J * MF1

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bbc3tm1Ast/Bbc3tm1Ast
Genetic Background: C57BL/6-Bbc3tm1Ast

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Bbc3tm1Ast/Bbc3tm1Ast
Genetic Background: C57BL/6-Bbc3tm1Ast

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bbc3tm1Ast/Bbc3tm1Ast
Genetic Background: C57BL/6-Bbc3tm1Ast

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: KitW-v/KitW-v,Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010754 abnormal heart left ventricle pressure "any anomaly in the pressure within the left cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ercc1tm1Dwm/Ercc1tm2Dwm,Hrhr/Hrhr,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J * MF1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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